PMID- 10898096
OWN - NLM
STAT- MEDLINE
DCOM- 20001025
LR  - 20131121
IS  - 0867-5910 (Print)
IS  - 0867-5910 (Linking)
VI  - 51
IP  - 2
DP  - 2000 Jun
TI  - Cardiovascular effects of histamine administered intracerebroventricularly in 
      critical haemorrhagic hypotension in rats.
PG  - 229-39
AB  - The study was designed to determine the cardiovascular effects of histamine 
      administered intracerebroventricularly (icv) in a rat model of volume-controlled 
      haemorrhagic shock. The withdrawal of approximately 50% of total blood volume 
      resulted in the death of all control saline icv treated animals within 30 min. 
      Icv injection of histamine produced a prompt dose-dependent (0.1-100 nmol) and 
      long-lasting (10-100 nmol) increase in mean arterial pressure (MAP), pulse 
      pressure (PP) and heart rate (HR), with a 100% survival of 2h after treatment 
      (100 nmol). The increase in MAP and HR after histamine administration in bled 
      rats in comparison to the normovolaemic animals was 2.7-3.3- and 1.3-3.6-fold 
      higher, respectively. Pretreatment with chlorpheniramine (50 nmol icv), H1 
      receptor antagonist, inhibited the increase in MAP, PP, HR and survival rate 
      produced by histamine, while chlorpheniramine given alone had no effect. Neither 
      ranitidine (50 nmol icv), H2 histamine receptor antagonist, nor thioperamide (50 
      nmol icv), H3 receptor blocker, influenced the histamine action, however, when 
      given alone, both evoked the pressor effect with elongation of survival time. It 
      can be concluded that histamine administered icv reverses the haemorrhagic shock 
      conditions, and histamine H1 receptors are involved.
FAU - Jochem, J
AU  - Jochem J
AD  - Department of Physiology, Silesian Medical University, Zabrze, Poland.
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - J Physiol Pharmacol
JT  - Journal of physiology and pharmacology : an official journal of the Polish 
      Physiological Society
JID - 9114501
RN  - 0 (Histamine Antagonists)
RN  - 0 (Histamine H1 Antagonists)
RN  - 3U6IO1965U (Chlorpheniramine)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Blood Volume
MH  - Cardiovascular System/*drug effects
MH  - Chlorpheniramine/pharmacology
MH  - *Critical Illness
MH  - Heart Rate/drug effects
MH  - Hemorrhage/*complications
MH  - Histamine/*administration & dosage/pharmacology
MH  - Histamine Antagonists/pharmacology
MH  - Histamine H1 Antagonists/pharmacology
MH  - Hypotension/*etiology/*physiopathology
MH  - Injections, Intraventricular
MH  - Male
MH  - Pressure
MH  - Pulse
MH  - Rats
MH  - Rats, Wistar
MH  - Reference Values
MH  - Shock, Hemorrhagic/physiopathology
MH  - Survival Analysis
EDAT- 2000/07/18 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/07/18 11:00
PHST- 2000/07/18 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/07/18 11:00 [entrez]
PST - ppublish
SO  - J Physiol Pharmacol. 2000 Jun;51(2):229-39.