PMID- 10898098
OWN - NLM
STAT- MEDLINE
DCOM- 20001025
LR  - 20141120
IS  - 0867-5910 (Print)
IS  - 0867-5910 (Linking)
VI  - 51
IP  - 2
DP  - 2000 Jun
TI  - A long-term fish diet modifies the toxic properties of human partially oxidized 
      LDL on vascular preparations in vitro.
PG  - 251-65
AB  - Both LDL oxidation and LDL fatty acid composition affect vascular relaxation and 
      contraction. The aim of this study was to investigate whether long-lasting 
      dietary habits (vegetarian, fish and high saturated fat as a control group) can 
      change those properties of partially oxidized LDL (ox-LDL) which are reflected in 
      altered vascular responses measured with a bioassay. The effects of ox-LDL were 
      investigated on rat mesenteric arteries. In endothelium intact arterial rings the 
      contractile responses to noradrenaline (NA) tended to be diminished in the 
      presence of ox-LDL derived from the fish diet group compared with the other 
      groups. In the endothelium denuded arterial rings the contractile responses to NA 
      and KCl were significantly enhanced by ox-LDL from the fish diet group compared 
      with the control group. The ox-LDL from the fish diet group increased the 
      diclofenac, L-NAME resistant relaxations to ACh compared to the control diet 
      group suggesting the role of endothelium derived hyperpolarizing factor (EDHF). 
      In conclusion, partially oxidized LDL from subjects living on a fish diet is 
      biologically more vasoactive in bioassay systems than partially oxidized LDL from 
      those living on vegetarian or saturated fatty acid containing diets. The impaired 
      responses in vasoconstriction and improved vasodilation seem to be endothelium 
      dependent.
FAU - Seppo, L
AU  - Seppo L
AD  - Institute of Biomedicine, Department of Pharmacology and Toxicology, University 
      of Helsinki, Finland.
FAU - Karjala, K
AU  - Karjala K
FAU - Nevala, R
AU  - Nevala R
FAU - Korpela, R
AU  - Korpela R
FAU - Lahteenmaki, T
AU  - Lahteenmaki T
FAU - Solatunturi, E
AU  - Solatunturi E
FAU - Tikkanen, M J
AU  - Tikkanen MJ
FAU - Vapaatalo, H
AU  - Vapaatalo H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - J Physiol Pharmacol
JT  - Journal of physiology and pharmacology : an official journal of the Polish 
      Physiological Society
JID - 9114501
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Fatty Acids)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Vasoconstrictor Agents)
RN  - 0 (Vasodilator Agents)
RN  - 0 (oxidized low density lipoprotein)
RN  - 144O8QL0L1 (Diclofenac)
RN  - 660YQ98I10 (Potassium Chloride)
RN  - N9YNS0M02X (Acetylcholine)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Acetylcholine/pharmacology
MH  - Adult
MH  - Animals
MH  - Cyclooxygenase Inhibitors/pharmacology
MH  - Diclofenac/pharmacology
MH  - *Diet
MH  - Diet, Vegetarian
MH  - Drug Resistance
MH  - Endothelium, Vascular/drug effects
MH  - Enzyme Inhibitors/pharmacology
MH  - Fatty Acids/administration & dosage
MH  - Female
MH  - *Fishes
MH  - Humans
MH  - In Vitro Techniques
MH  - Lipoproteins, LDL/*poisoning
MH  - Male
MH  - Mesenteric Arteries/*drug effects/physiology
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Norepinephrine/pharmacology
MH  - Potassium Chloride/pharmacology
MH  - Time Factors
MH  - Vasoconstriction/drug effects
MH  - Vasoconstrictor Agents/pharmacology
MH  - Vasodilation/drug effects
MH  - Vasodilator Agents/pharmacology
EDAT- 2000/07/18 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/07/18 11:00
PHST- 2000/07/18 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/07/18 11:00 [entrez]
PST - ppublish
SO  - J Physiol Pharmacol. 2000 Jun;51(2):251-65.