PMID- 10898249
OWN - NLM
STAT- MEDLINE
DCOM- 20000726
LR  - 20190513
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 55
IP  - 7
DP  - 2000 Jul
TI  - In vitro oxidation of low-density lipoprotein in two species of nonhuman primates 
      subjected to caloric restriction.
PG  - B355-61
AB  - Caloric restriction (CR), which increases longevity and retards age-associated 
      diseases in laboratory rodents, is being evaluated in nonhuman primate trials. CR 
      reduces oxidative stress in rodents and appears to improve risk factors for 
      cardiovascular disease in nonhuman primates. We tested the hypothesis that 
      low-density lipoprotein (LDL) oxidizability is reduced in two monkey species 
      (rhesus and cynomolgus) subjected to chronic CR. In both species, no significant 
      differences occurred between CR and control animals on total, LDL, or 
      high-density lipoprotein (HDL) cholesterol. In rhesus monkeys, triglycerides were 
      higher in controls than CR (139 +/- 23 vs 66 +/- 8 mg/dl,p < .01, respectively). 
      LDL from CR rhesus monkeys was reduced in triglyceride content and molecular 
      weight compared to controls, whereas LDL composition in cynomolgus monkeys was 
      similar in CR and control animals. In keeping with minor deviations in lipids, 
      antioxidants, and LDL composition, no consistent differences in in vitro LDL 
      oxidizability were apparent between CR and controls in either species.
FAU - Cefalu, W T
AU  - Cefalu WT
AD  - Department of Medicine, University of Vermont College of Medicine, Burlington 
      05405, USA. wcefalu@zoo.uvm.edu
FAU - Terry, J G
AU  - Terry JG
FAU - Thomas, M J
AU  - Thomas MJ
FAU - Morgan, T M
AU  - Morgan TM
FAU - Edwards, I J
AU  - Edwards IJ
FAU - Rudel, L L
AU  - Rudel LL
FAU - Kemnitz, J W
AU  - Kemnitz JW
FAU - Weindruch, R
AU  - Weindruch R
LA  - eng
GR  - K01AG00578/AG/NIA NIH HHS/United States
GR  - P01AG11915/AG/NIA NIH HHS/United States
GR  - R29AG10816/AG/NIA NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Triglycerides)
RN  - 1406-18-4 (Vitamin E)
SB  - IM
MH  - Animals
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - *Energy Intake
MH  - Female
MH  - In Vitro Techniques
MH  - Lipids/blood
MH  - Lipoproteins, LDL/chemistry/*metabolism
MH  - Macaca fascicularis
MH  - Macaca mulatta
MH  - Male
MH  - Oxidation-Reduction
MH  - Oxidative Stress
MH  - Triglycerides/blood
MH  - Vitamin E/blood
EDAT- 2000/07/18 11:00
MHDA- 2000/08/01 11:00
CRDT- 2000/07/18 11:00
PHST- 2000/07/18 11:00 [pubmed]
PHST- 2000/08/01 11:00 [medline]
PHST- 2000/07/18 11:00 [entrez]
AID - 10.1093/gerona/55.7.b355 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2000 Jul;55(7):B355-61. doi: 
      10.1093/gerona/55.7.b355.