PMID- 1090148
OWN - NLM
STAT- MEDLINE
DCOM- 19750510
LR  - 20190626
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 58
IP  - 1
DP  - 1975 Jan
TI  - Selective hypogammaglobulinemia with persistence of IgE, malabsorption and a 
      nutritionally dependent, reversible defect in cell-mediated immunity.
PG  - 129-34
AB  - A 46 year old man presented with selective hypogammaglobulinemia, malabsorption 
      and long-standing secondary malnutrition. Although the patient had essentially 
      unmeasurable levels of immunoglobulins G (IgG), M (IgA), he had normal levels of 
      immunoglobulin E (IgE). He was found to be anergic when tested for the delayed 
      cutaneous hypersensitivity reaction. Evaluation of his cell-mediated immunity in 
      vivo and in vitro suggested one discrete lesion, a defective production of the 
      lymphocyte mediator macrophage migration inhibitory factor. With improved 
      nutrition the patient "repaired" this defect in the "efferent" limb of cellular 
      immunity and was no longer anergic.
FAU - Levin, D M
AU  - Levin DM
FAU - Lipsky, P E
AU  - Lipsky PE
FAU - Kirkpatrick, C H
AU  - Kirkpatrick CH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Macrophage Migration-Inhibitory Factors)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Agammaglobulinemia/*immunology
MH  - Diet
MH  - Humans
MH  - *Immunity, Cellular
MH  - Immunoglobulin A/analysis
MH  - Immunoglobulin E/*analysis
MH  - Immunoglobulin G/analysis
MH  - Immunoglobulin M/analysis
MH  - Immunologic Deficiency Syndromes/*immunology
MH  - Intestinal Mucosa/immunology
MH  - Macrophage Migration-Inhibitory Factors/deficiency
MH  - Macrophages/immunology
MH  - Malabsorption Syndromes/etiology/*immunology
MH  - Male
MH  - Middle Aged
MH  - Nutrition Disorders/etiology/immunology
MH  - Skin Tests
EDAT- 1975/01/01 00:00
MHDA- 1975/01/01 00:01
CRDT- 1975/01/01 00:00
PHST- 1975/01/01 00:00 [pubmed]
PHST- 1975/01/01 00:01 [medline]
PHST- 1975/01/01 00:00 [entrez]
AID - 0002-9343(75)90543-4 [pii]
AID - 10.1016/0002-9343(75)90543-4 [doi]
PST - ppublish
SO  - Am J Med. 1975 Jan;58(1):129-34. doi: 10.1016/0002-9343(75)90543-4.