PMID- 10903234
OWN - NLM
STAT- MEDLINE
DCOM- 20000913
LR  - 20220309
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 162
IP  - 1
DP  - 2000 Jul
TI  - Increased numbers of dendritic cells in the bronchiolar tissues of diffuse 
      panbronchiolitis.
PG  - 148-53
AB  - Dendritic cells (DCs) are potent antigen-presenting cells (APCs); they are 
      considered to be the most important APC in the lung. Recently, the number of DCs 
      in the large airways was demonstrated to increase in patients with atopic asthma, 
      leading to the concept that DCs play an important role in airway inflammation. 
      However, little is known about the distribution of lung DCs in the small airways 
      under other pathological conditions. The aim of the present study was to examine 
      the distribution of DCs in the bronchiolar tissues in patients with diffuse 
      panbronchiolitis (DPB), which is a chronic inflammatory disorder of the airways 
      histologically characterized by peribronchiolitis. We investigated the 
      distribution of DCs in the bronchiolar tissues of the lungs in 11 patients with 
      DPB and 7 control subjects with normal lungs using immunohistochemical methods. 
      Marked increases in the number of CD1a(+), CD1c(+), and CD83(+) DCs were found in 
      both the bronchiolar epithelium and submucosal tissues of patients with DPB, 
      compared with control subjects with normal lungs. The most striking increase 
      occurred in the number of DCs expressing CD83, a marker of mature DCs, in the 
      submucosal tissues of patients with DPB. The increases of these positive cells in 
      patients with DPB were more marked in the submucosal tissues than in the 
      epithelium. The bronchiolar epithelial cells in patients with DPB strongly 
      expressed GM-CSF protein, which is an important cytokine for the differentiation 
      and function of DCs, suggesting that the increased local production of GM-CSF may 
      be responsible for the accumulation and differentiation of DCs in the bronchiolar 
      tissues of patients with DPB. These results suggest that increased DCs in the 
      bronchiolar tissues, together with their phenotypical maturation, may play an 
      important role in the mucosal immune response in patients with DPB through their 
      potent antigen-presenting function.
FAU - Todate, A
AU  - Todate A
AD  - Second Division of Internal Medicine, Hamamatsu University School of Medicine, 
      Hamamatsu, Shizuoka, Japan.
FAU - Chida, K
AU  - Chida K
FAU - Suda, T
AU  - Suda T
FAU - Imokawa, S
AU  - Imokawa S
FAU - Sato, J
AU  - Sato J
FAU - Ide, K
AU  - Ide K
FAU - Tsuchiya, T
AU  - Tsuchiya T
FAU - Inui, N
AU  - Inui N
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Asada, K
AU  - Asada K
FAU - Hayakawa, H
AU  - Hayakawa H
FAU - Nakamura, H
AU  - Nakamura H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Antigens, CD)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, CD/biosynthesis
MH  - Bronchi/*pathology
MH  - Bronchiolitis/*pathology
MH  - Cell Count
MH  - *Dendritic Cells/immunology
MH  - Female
MH  - Humans
MH  - Macrophages
MH  - Male
MH  - Middle Aged
EDAT- 2000/07/21 11:00
MHDA- 2000/09/19 11:01
CRDT- 2000/07/21 11:00
PHST- 2000/07/21 11:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 2000/07/21 11:00 [entrez]
AID - 10.1164/ajrccm.162.1.9907015 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2000 Jul;162(1):148-53. doi: 
      10.1164/ajrccm.162.1.9907015.