PMID- 10903257
OWN - NLM
STAT- MEDLINE
DCOM- 20000913
LR  - 20220419
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 162
IP  - 1
DP  - 2000 Jul
TI  - Pneumoconiosis-related lung cancers: preferential occurrence from diffuse 
      interstitial fibrosis-type pneumoconiosis.
PG  - 295-300
AB  - It has been reported that patients with pneumoconiosis occasionally have a 
      diffuse interstitial fibrosis (DIF) that resembles interstitial pneumonia, but 
      little is known about the relation between pneumoconiosis-associated DIF and the 
      risk of lung cancer. In the present study, we evaluated the incidence of DIF by 
      chest CT and its contribution to lung cancer in 563 patients with nonasbestos 
      pneumoconiosis. Fifty-five (10%) of the 563 patients had DIF. Pneumoconiosis with 
      DIF had an exceedingly high concurrence of lung cancers when compared with 
      pneumoconiosis without DIF (29 [53%] of 55 versus 78 [15%] of 508, p < 0.001). 
      Squamous cell carcinomas (SCCs) of the lung from pneumoconiosis with DIF 
      exclusively comprised peripheral-types, as compared with SCCs from pneumoconiosis 
      without DIF (13 [100%] of 13 versus 33 [72%] of 46, p = 0.03). In addition, lung 
      cancers arose frequently from the area of DIF in pneumoconiosis with DIF (20 
      [74%] of 27). Furthermore, our pathologic examination revealed that dysplasias 
      from pneumoconiosis with DIF were significantly more frequently observed in 
      peripheral bronchioli than were dysplasias from pneumoconiosis without DIF (11 
      [69%] of 16 versus 20 [30%] of 66, p = 0.01). p53 expression evaluated by 
      immunohistochemistry was frequently observed in dysplasias from pneumoconiosis 
      with DIF, although it was not significantly different compared with that in 
      dysplasias from pneumoconiosis without DIF (5 [50%] of 10 versus 12 [38%] of 32). 
      Taken together, these results may suggest a positive causal relationship between 
      pneumoconiosis and peripheral-type SCCs of the lung, and further indicate a 
      pivotal role of diffuse fibrosis for the excess incidence of lung cancers, 
      especially peripheral-type SCCs, in DIF-type pneumoconiosis.
FAU - Katabami, M
AU  - Katabami M
AD  - Iwamizawa Rosai Hospital, Iwamizawa, Japan.
FAU - Dosaka-Akita, H
AU  - Dosaka-Akita H
FAU - Honma, K
AU  - Honma K
FAU - Saitoh, Y
AU  - Saitoh Y
FAU - Kimura, K
AU  - Kimura K
FAU - Uchida, Y
AU  - Uchida Y
FAU - Mikami, H
AU  - Mikami H
FAU - Ohsaki, Y
AU  - Ohsaki Y
FAU - Kawakami, Y
AU  - Kawakami Y
FAU - Kikuchi, K
AU  - Kikuchi K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Aged
MH  - Humans
MH  - Incidence
MH  - Lung Diseases, Interstitial/*complications/metabolism/pathology
MH  - Lung Neoplasms/*epidemiology/*etiology/metabolism/pathology
MH  - Pneumoconiosis/*complications/metabolism/pathology
MH  - Pulmonary Fibrosis/*complications/metabolism/pathology
MH  - Tumor Suppressor Protein p53/analysis/biosynthesis
EDAT- 2000/07/21 11:00
MHDA- 2000/09/19 11:01
CRDT- 2000/07/21 11:00
PHST- 2000/07/21 11:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 2000/07/21 11:00 [entrez]
AID - 10.1164/ajrccm.162.1.9906138 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2000 Jul;162(1):295-300. doi: 
      10.1164/ajrccm.162.1.9906138.