PMID- 10903573
OWN - NLM
STAT- MEDLINE
DCOM- 20000815
LR  - 20220311
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 3
IP  - 8
DP  - 2000 Aug
TI  - Maternal care, hippocampal synaptogenesis and cognitive development in rats.
PG  - 799-806
AB  - We report that variations in maternal care in the rat promote hippocampal 
      synaptogenesis and spatial learning and memory through systems known to mediate 
      experience-dependent neural development. Thus, the offspring of mothers that show 
      high levels of pup licking and grooming and arched-back nursing showed increased 
      expression of NMDA receptor subunit and brain-derived neurotrophic factor (BDNF) 
      mRNA, increased cholinergic innervation of the hippocampus and enhanced spatial 
      learning and memory. A cross-fostering study provided evidence for a direct 
      relationship between maternal behavior and hippocampal development, although not 
      all neonates were equally sensitive to variations in maternal care.
FAU - Liu, D
AU  - Liu D
AD  - Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, 
      Departments of Psychiatry and Neurology & Neurosurgery, McGill University, 6875 
      Boul. LaSalle, Montreal H4H 1R3, Canada.
FAU - Diorio, J
AU  - Diorio J
FAU - Day, J C
AU  - Day JC
FAU - Francis, D D
AU  - Francis DD
FAU - Meaney, M J
AU  - Meaney MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognition/*physiology
MH  - Female
MH  - *Gene Expression Regulation, Developmental
MH  - Grooming
MH  - Hippocampus/growth & development/*physiology
MH  - Maternal Behavior/*physiology/psychology
MH  - Neurons/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptors, N-Methyl-D-Aspartate/*genetics
MH  - Synapses/*physiology
EDAT- 2000/07/21 11:00
MHDA- 2000/08/19 11:00
CRDT- 2000/07/21 11:00
PHST- 2000/07/21 11:00 [pubmed]
PHST- 2000/08/19 11:00 [medline]
PHST- 2000/07/21 11:00 [entrez]
AID - 10.1038/77702 [doi]
PST - ppublish
SO  - Nat Neurosci. 2000 Aug;3(8):799-806. doi: 10.1038/77702.