PMID- 10906222
OWN - NLM
STAT- MEDLINE
DCOM- 20000818
LR  - 20190508
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 74
IP  - 16
DP  - 2000 Aug
TI  - Complete DNA sequence of the rat cytomegalovirus genome.
PG  - 7656-65
AB  - We have determined the complete genome sequence of the Maastricht strain of rat 
      cytomegalovirus (RCMV). The RCMV genome has a length of 229,896 bp and is 
      arranged as a single unique sequence flanked by 504-bp terminal direct repeats. 
      RCMV was found to have counterparts of all but one of the open reading frames 
      (ORFs) that are conserved between murine CMV (MCMV) and human CMV (HCMV). Like 
      HCMV, RCMV lacks homologs of the genes belonging to the MCMV m02 glycoprotein 
      gene family. However, RCMV contains 15 ORFs with homology to members of the MCMV 
      m145 glycoprotein gene family. Four ORFs are predicted to encode homologs of host 
      proteins; R33 and R78 both putatively encode G protein-coupled receptors, whereas 
      r144 and r131 encode homologs of major histocompatibility class I heavy chains 
      and CC chemokines, respectively. An intriguing feature of the RCMV genome is the 
      presence of an ORF, r127, with similarity to the rep gene of parvoviruses as well 
      as ORF U94 of human herpesvirus 6A (HHV-6A) and HHV-6B. Counterparts of these 
      ORFs have not been found in the other sequenced herpesviruses.
FAU - Vink, C
AU  - Vink C
AD  - Department of Medical Microbiology, Cardiovascular Research Institute Maastricht, 
      University of Maastricht, 6202 AZ Maastricht, The Netherlands. kvi@lmib.azm.nl
FAU - Beuken, E
AU  - Beuken E
FAU - Bruggeman, C A
AU  - Bruggeman CA
LA  - eng
SI  - GENBANK/AF232689
PT  - Journal Article
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (DNA, Viral)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - DNA Replication/genetics
MH  - DNA, Viral/metabolism
MH  - *Genome, Viral
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Muromegalovirus/*genetics
MH  - Open Reading Frames/genetics
MH  - RNA Splicing
MH  - Rats
MH  - Sequence Alignment
MH  - *Sequence Analysis, DNA
MH  - Viral Proteins/chemistry/genetics
PMC - PMC112289
EDAT- 2000/07/25 11:00
MHDA- 2000/08/29 11:01
PMCR- 2000/08/01
CRDT- 2000/07/25 11:00
PHST- 2000/07/25 11:00 [pubmed]
PHST- 2000/08/29 11:01 [medline]
PHST- 2000/07/25 11:00 [entrez]
PHST- 2000/08/01 00:00 [pmc-release]
AID - 0308 [pii]
AID - 10.1128/jvi.74.16.7656-7665.2000 [doi]
PST - ppublish
SO  - J Virol. 2000 Aug;74(16):7656-65. doi: 10.1128/jvi.74.16.7656-7665.2000.