PMID- 10907736
OWN - NLM
STAT- MEDLINE
DCOM- 20000822
LR  - 20151026
IS  - 0300-9564 (Print)
IS  - 0300-9564 (Linking)
VI  - 106
IP  - 7-8
DP  - 1999
TI  - Alterations in hippocampal and hypothalamic monoaminergic neurotransmitter 
      systems after alcohol exposure during all three trimester equivalents in adult 
      rats.
PG  - 773-86
AB  - Animal models of Fetal Alcohol Syndrome (FAS) often rely on exposing the 
      developing organism to alcohol during either the prenatal or postnatal period 
      only. Very few studies have examined brain changes resulting from alcohol 
      exposure during both the prenatal and postnatal period, a period which is 
      equivalent to all three trimesters in humans. In this study, we examined the 
      effects of alcohol exposure during this prolonged period of neural development on 
      hippocampal and hypothalamic neurotransmitters in the rat. Pregnant dams were 
      intubated with alcohol from gestational day (GD) 1 to GD 22 and then their pups 
      were intubated with alcohol from postnatal day (PD) 2 to PD 10. Alcohol-exposed 
      rats of both sexes exhibited increased hippocampal noradrenaline (NE) 
      concentration compared to intubated and nontreated control animals. Within the 
      hypothalamus, alcohol-exposed females but not males exhibited increased NE 
      concentration. Hypothalamic serotonin (5-HT) concentration was reduced in both 
      alcohol-exposed and intubated-control rats compared to nontreated controls. The 
      results suggest that both the hippocampal and hypothalamic NE systems are 
      especially vulnerable to alcohol insult that occurs during a period of neural 
      development that corresponds to the full human prenatal period. alcohol syndrome, 
      hippocampus, hypothalamus,
FAU - Tran, T D
AU  - Tran TD
AD  - Department of Psychology, University of South Carolina, Columbia 29208, USA.
FAU - Kelly, S J
AU  - Kelly SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Central Nervous System Depressants/*pharmacology
MH  - Ethanol/*pharmacology
MH  - Female
MH  - Hippocampus/*drug effects/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Hypothalamus/*drug effects/metabolism
MH  - Male
MH  - Norepinephrine/*metabolism
MH  - Pregnancy
MH  - Rats
MH  - Sex Factors
EDAT- 2000/07/25 11:00
MHDA- 2000/08/29 11:01
CRDT- 2000/07/25 11:00
PHST- 2000/07/25 11:00 [pubmed]
PHST- 2000/08/29 11:01 [medline]
PHST- 2000/07/25 11:00 [entrez]
AID - 10.1007/s007020050198 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 1999;106(7-8):773-86. doi: 10.1007/s007020050198.