PMID- 10907959
OWN - NLM
STAT- MEDLINE
DCOM- 20001228
LR  - 20200203
IS  - 0923-7534 (Print)
IS  - 0923-7534 (Linking)
VI  - 11
IP  - 5
DP  - 2000 May
TI  - Is the international prognostic score for advanced stage Hodgkin's disease 
      applicable to early stage patients? German Hodgkin Lymphoma Study Group.
PG  - 617-23
AB  - BACKGROUND: The seven-factor International Prognostic Score (IPS) has been 
      developed and verified for patients with advanced stage Hodgkin's disease (HD). 
      This report aims to assess the predictive power of the IPS for early stage HD 
      patients. PATIENTS AND METHODS: Data on patient characteristics, therapy and 
      follow-up were available for 1424 adult patients in clinical stages I-IIIA 
      treated for primary HD in two German Hodgkin's Lymphoma Study Group (GHSG) trials 
      (1988-1994). Patients with risk factors or in stage IIIA received chemo 
      radiotherapy (CMT; trial HD5); others received extended field radiotherapy (RT) 
      alone (HD4). The IPS could be calculated for 712 HD5 and 249 HD4 patients (70%). 
      The prognostic value of the IPS and its component factors was assessed using Cox 
      proportional hazards regression. A search was made for additional factors which 
      could add predictive power to the IPS. RESULTS: The IPS identified 40% of the 
      unfavourable early stage patients with an 8% lower disease-free survival at six 
      years (hazard ratio 1.66, P = 0.0018). The factor 'low albumin' was the only 
      score component giving a significant individual contribution. Allowing for the 
      IPS, extranodal involvement, particularly in stages IIB-IIIA, was associated with 
      worse prognosis, but no further significantly prognostic factors were revealed. 
      The IPS identified a similar hazard ratio in HD4, although here the effect was 
      not significant. CONCLUSIONS: The IPS for advanced HD has modest predictive 
      ability in unfavourable early stage patients. Modification of the IPS for use 
      with early stages may improve its prognostic power.
FAU - Franklin, J
AU  - Franklin J
AD  - Department of Internal Medicine, Unirersity of Cologne, Germany. 
      jeremy_franklin@biometrie.uni-koeln.de
FAU - Paulus, U
AU  - Paulus U
FAU - Lieberz, D
AU  - Lieberz D
FAU - Breuer, K
AU  - Breuer K
FAU - Tesch, H
AU  - Tesch H
FAU - Diehl, V
AU  - Diehl V
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical 
      Oncology
JID - 9007735
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Disease-Free Survival
MH  - Female
MH  - Hodgkin Disease/classification/*pathology
MH  - Humans
MH  - International Cooperation
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging/*methods
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2000/07/25 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/07/25 11:00
PHST- 2000/07/25 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/07/25 11:00 [entrez]
AID - S0923-7534(19)55070-0 [pii]
AID - 10.1023/a:1008325627670 [doi]
PST - ppublish
SO  - Ann Oncol. 2000 May;11(5):617-23. doi: 10.1023/a:1008325627670.