PMID- 10908909
OWN - NLM
STAT- MEDLINE
DCOM- 20000815
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 55
IP  - 2
DP  - 2000 Jul 25
TI  - Striatal serotonin is depleted in brain of a human MDMA (Ecstasy) user.
PG  - 294-6
AB  - The authors found that striatal levels of serotonin and those of its metabolite 
      5-hydroxyindoleacetic acid were severely depleted by 50 to 80% in brain of a 
      chronic user of methylenedioxymethamphetamine (MDMA) whereas concentrations of 
      dopamine were within the normal control range. Our data suggest that MDMA 
      exposure in the human can cause decreased tissue stores of serotonin and 
      therefore some of the behavioral effects of this drug of abuse could be caused by 
      massive release and depletion of brain serotonin.
FAU - Kish, S J
AU  - Kish SJ
AD  - Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 
      Toronto, Canada.
FAU - Furukawa, Y
AU  - Furukawa Y
FAU - Ang, L
AU  - Ang L
FAU - Vorce, S P
AU  - Vorce SP
FAU - Kalasinsky, K S
AU  - Kalasinsky KS
LA  - eng
GR  - DA 7182/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Corpus Striatum/*pathology
MH  - Dopamine/metabolism
MH  - Female
MH  - Humans
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - *N-Methyl-3,4-methylenedioxyamphetamine
MH  - Occipital Lobe/pathology
MH  - Reference Values
MH  - Serotonin/*metabolism
MH  - *Serotonin Agents
MH  - Substance-Related Disorders/*pathology
EDAT- 2000/07/26 11:00
MHDA- 2000/08/19 11:00
CRDT- 2000/07/26 11:00
PHST- 2000/07/26 11:00 [pubmed]
PHST- 2000/08/19 11:00 [medline]
PHST- 2000/07/26 11:00 [entrez]
AID - 10.1212/wnl.55.2.294 [doi]
PST - ppublish
SO  - Neurology. 2000 Jul 25;55(2):294-6. doi: 10.1212/wnl.55.2.294.