PMID- 10913669
OWN - NLM
STAT- MEDLINE
DCOM- 20000809
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 120
IP  - 1
DP  - 2000 Jul 1
TI  - Analysis of the P53, RB/D13S25, and P16 tumor suppressor genes in marginal zone 
      B-cell lymphoma: An interphase fluorescence in situ hybridization study.
PG  - 1-5
AB  - The genetic mechanisms underlying the genesis, disease progression, and 
      high-grade transformation of marginal zone B-cell lymphoma (MZBCL) are poorly 
      understood. We analyzed 33 cases of histologically and immunophenotypically 
      well-characterized MZBCL (12 extranodal, 11 nodal, and 10 splenic MZBCL; 27 at 
      primary diagnosis and six during the course of disease) by dual-color interphase 
      fluorescence in situ hybridization (FISH) for deletions of tumor suppressor 
      genes. We investigated loci known to play a role in the genesis or disease 
      progression of other subtypes of lymphoid malignancies, namely the P53 gene 
      (17p13), the retinoblastoma gene (RB, 13q14), the D13S25 locus (13q14), and the 
      P16(INK4A) gene (9p21). Heterozygous deletions of P53 were detected in three out 
      of the 33 cases, including two splenic and one extranodal MZBCL. One of these 
      patients was analyzed at primary diagnosis and two during the course of disease. 
      Heterozygous deletions of the RB gene (nodal MZBCL) and D13S25 (splenic MZBCL) 
      were found in one case each. P16 deletions were not detected in any of our cases. 
      We conclude that deletions of the analyzed tumor suppressor genes are relatively 
      rare in MZBCL, which contrasts with the findings in some other subtypes of NHL.
FAU - Dierlamm, J
AU  - Dierlamm J
AD  - Department of Oncology and Hematology, University Hospital Eppendorf, Hamburg, 
      Germany.
FAU - Stefanova, M
AU  - Stefanova M
FAU - Wlodarska, I
AU  - Wlodarska I
FAU - Hinz, K
AU  - Hinz K
FAU - Maes, B
AU  - Maes B
FAU - Michaux, L
AU  - Michaux L
FAU - Stul, M
AU  - Stul M
FAU - Verhoef, G
AU  - Verhoef G
FAU - Thomas, J
AU  - Thomas J
FAU - De Wolf-Peeters, C
AU  - De Wolf-Peeters C
FAU - Van den Berghe, H
AU  - Van den Berghe H
FAU - Hossfeld, D K
AU  - Hossfeld DK
FAU - Hagemeijer, A
AU  - Hagemeijer A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Female
MH  - *Gene Deletion
MH  - Genes, Retinoblastoma/*genetics
MH  - Genes, p16/*genetics
MH  - Genes, p53/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Lymphoma, B-Cell/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 2000/07/29 11:00
MHDA- 2000/08/12 11:00
CRDT- 2000/07/29 11:00
PHST- 2000/07/29 11:00 [pubmed]
PHST- 2000/08/12 11:00 [medline]
PHST- 2000/07/29 11:00 [entrez]
AID - S0165-4608(99)00239-3 [pii]
AID - 10.1016/s0165-4608(99)00239-3 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Jul 1;120(1):1-5. doi: 
      10.1016/s0165-4608(99)00239-3.