PMID- 10913680
OWN - NLM
STAT- MEDLINE
DCOM- 20000809
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 120
IP  - 1
DP  - 2000 Jul 1
TI  - A PML/RARA chimeric gene on chromosome 2 in a patient with acute promyelocytic 
      leukemia (M3) associated with a new variant translocation: 
      t(2;15;17)(q21;q22;q21).
PG  - 80-2
AB  - We describe a patient with acute promyelocytic leukemia (APL) carrying a new 
      complex variant translocation of t(2;15;17)(q21;q22;q21). The karyotypic 
      interpretation was confirmed by fluorescence in situ hybridization (FISH) with 
      the use of painting probes of chromosomes 2, 15, and 17 and a PML/RARA dual color 
      DNA probe. FISH showed a PML/RARA fusion gene on the der(2) instead of the 
      der(15). These results suggest that the critical event in the development of APL 
      is the formation of a PML/RARA chimeric gene, regardless of its locus in the 
      genome.
FAU - Fujishima, M
AU  - Fujishima M
AD  - Third Department of Internal Medicine, Akita, Japan.
FAU - Takahashi, N
AU  - Takahashi N
FAU - Miura, I
AU  - Miura I
FAU - Kobayashi, Y
AU  - Kobayashi Y
FAU - Kume, M
AU  - Kume M
FAU - Nishinari, T
AU  - Nishinari T
FAU - Miura, A B
AU  - Miura AB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein)
SB  - IM
MH  - Chromosomes, Human, Pair 15
MH  - Chromosomes, Human, Pair 17
MH  - *Chromosomes, Human, Pair 2
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Promyelocytic, Acute/*genetics
MH  - *Neoplasm Proteins/*genetics
MH  - *Oncogene Proteins, Fusion/*genetics
MH  - *Translocation, Genetic
EDAT- 2000/07/29 11:00
MHDA- 2000/08/12 11:00
CRDT- 2000/07/29 11:00
PHST- 2000/07/29 11:00 [pubmed]
PHST- 2000/08/12 11:00 [medline]
PHST- 2000/07/29 11:00 [entrez]
AID - S0165-4608(99)00238-1 [pii]
AID - 10.1016/s0165-4608(99)00238-1 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Jul 1;120(1):80-2. doi: 
      10.1016/s0165-4608(99)00238-1.