PMID- 10914679
OWN - NLM
STAT- MEDLINE
DCOM- 20000808
LR  - 20190722
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 106
IP  - 5
DP  - 2000 May
TI  - Interchromosomal effects for chromosome 21 in carriers of structural chromosome 
      reorganizations determined by fluorescence in situ hybridization on sperm nuclei.
PG  - 500-5
AB  - We have used dual color fluorescence in situ hybridization (FISH) on decondensed 
      sperm heads from four carriers of structural chromosome reorganizations, viz. 
      t(3;15), t(Y;7), t(13;22) and inv(9), to assess the possible existence of an 
      interchromosomal effect (ICE) on the segregation of chromosome 21. In the 
      carriers of t(Y;7), t(13;22) and inv(9), all results were within the limits 
      described in controls. A highly significant increase (P<0.0001) of disomy 21 
      (1.90% v 0.37%), which could be considered as a positive ICE, was observed in the 
      t(3;15) carrier. Significantly higher percentages (P<0.0001) of diploid sperm 
      (5.71% v. 0.27%) were also observed in this patient. Our results suggests that 
      the occurrence of an ICE may depend on the reorganization and on the chromosome 
      and chromosome regions involved, resulting in a particular meiotic behaviour 
      (presence of unsynapsed regions, preferential meiotic configurations) that could 
      lead to the observed increase in chromosome 21 disomies. Further studies with 
      this technical approach in a wide range of structural reorganizations could help 
      to elucidate the actual occurrence of ICEs.
FAU - Blanco, J
AU  - Blanco J
AD  - Unitat de Biologia Cellular, Universitat Autonoma de Barcelona, Bellaterra 
      (Cerdanyola del Valles), Spain.
FAU - Egozcue, J
AU  - Egozcue J
FAU - Vidal, F
AU  - Vidal F
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
MH  - Adult
MH  - Aneuploidy
MH  - Cell Nucleus/genetics
MH  - *Chromosome Aberrations
MH  - Chromosome Inversion
MH  - Chromosomes, Human, Pair 21/*genetics
MH  - Down Syndrome/genetics
MH  - Heterozygote
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/genetics
MH  - Male
MH  - Middle Aged
MH  - Spermatozoa/*ultrastructure
MH  - Translocation, Genetic
EDAT- 2000/07/29 11:00
MHDA- 2000/08/12 11:00
CRDT- 2000/07/29 11:00
PHST- 2000/07/29 11:00 [pubmed]
PHST- 2000/08/12 11:00 [medline]
PHST- 2000/07/29 11:00 [entrez]
AID - 10.1007/s004390000295 [doi]
PST - ppublish
SO  - Hum Genet. 2000 May;106(5):500-5. doi: 10.1007/s004390000295.