PMID- 10914923
OWN - NLM
STAT- MEDLINE
DCOM- 20000815
LR  - 20161124
IS  - 0161-5505 (Print)
IS  - 0161-5505 (Linking)
VI  - 41
IP  - 7
DP  - 2000 Jul
TI  - Intrinsic dual-energy processing of myocardial perfusion images.
PG  - 1287-97
AB  - We have developed a software-based method for processing dual-energy 201TI SPECT 
      emission projection data with the goal of calculating a spatially dependent index 
      of the local impact of gamma-ray attenuation. We refer to this method as 
      intrinsic dual-energy processing (IDEP). METHODS: IDEP exploits the differential 
      attenuation of lower energy emissions (69-83 keV) and higher energy emissions 
      (167 keV) resulting from the decay of 201TI to characterize the relative degree 
      of low-energy gamma-ray attenuation throughout the myocardium. In particular, 
      IDEP can be used to estimate the relative probability that a low-energy gamma-ray 
      emitted from a particular region of the myocardium is detected during the 
      acquisition of SPECT projection data. Studies on phantoms and healthy human 
      volunteers were performed to determine whether the IDEP method yielded detection 
      probability images with systematic structure visible above the noise of these 
      images and whether the systematic structure in the detection probability images 
      could be rationalized physically. In patient studies, the relative regional 
      detection probabilities were applied qualitatively to determine the likely 
      effects of attenuation on the distribution of mapped photon emissions. RESULTS: 
      Measurements of the detection probability in uniform phantoms showed excellent 
      agreement with those obtained from computer simulations for both 180 degrees and 
      360 degrees acquisitions. Additional simulations with digital phantoms showed 
      good correlation between IDEP-estimated detection probabilities and calculated 
      detection probabilities. In patient studies, the IDEP-derived detection 
      probability maps showed qualitative agreement with known nonuniform attenuation 
      characteristics of the human thorax. When IDEP data were integrated with the 
      findings on the emission scan, the correlation with coronary anatomy (known in 6 
      patients and hypothesized on the basis of clinical and electrocardiographic 
      parameters in 5 patients) was improved compared with evaluating the mapped 
      emission image alone. CONCLUSION: The IDEP method has the potential to 
      characterize the attenuation properties of an object without use of a separate 
      transmission scan. Coupled with the emission data, it may aid coronary diagnosis.
FAU - Brown, J K
AU  - Brown JK
AD  - Physics Research Laboratory, University of California, San Francisco, USA.
FAU - Tang, H R
AU  - Tang HR
FAU - Hattner, R S
AU  - Hattner RS
FAU - Bocher, M
AU  - Bocher M
FAU - Ratzlaff, N W
AU  - Ratzlaff NW
FAU - Kadkade, P P
AU  - Kadkade PP
FAU - Hasegawa, B H
AU  - Hasegawa BH
FAU - Botvinick, E H
AU  - Botvinick EH
LA  - eng
GR  - 2 R02 CA50539/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Nucl Med
JT  - Journal of nuclear medicine : official publication, Society of Nuclear Medicine
JID - 0217410
RN  - 0 (Thallium Radioisotopes)
RN  - 64ALC7F90C (Dipyridamole)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Computer Simulation
MH  - Dipyridamole
MH  - Exercise Test
MH  - Female
MH  - Heart/*diagnostic imaging
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - Male
MH  - Middle Aged
MH  - Phantoms, Imaging
MH  - Thallium Radioisotopes
MH  - Tomography, Emission-Computed, Single-Photon/*methods
EDAT- 2000/07/29 11:00
MHDA- 2000/08/19 11:00
CRDT- 2000/07/29 11:00
PHST- 2000/07/29 11:00 [pubmed]
PHST- 2000/08/19 11:00 [medline]
PHST- 2000/07/29 11:00 [entrez]
PST - ppublish
SO  - J Nucl Med. 2000 Jul;41(7):1287-97.