PMID- 10915397
OWN - NLM
STAT- MEDLINE
DCOM- 20000606
LR  - 20131121
IS  - 0741-238X (Print)
IS  - 0741-238X (Linking)
VI  - 16
IP  - 5
DP  - 1999 Sep-Oct
TI  - Tolerability and efficacy of high-dose furosemide and small-volume hypertonic 
      saline solution in refractory congestive heart failure.
PG  - 219-28
AB  - Thirty patients aged 65-85 years, with refractory New York Heart Association 
      (NYHA) class IV congestive heart failure (CHF) were treated with an intravenous 
      infusion of furosemide (250-2000 mg/d) and small-volume hypertonic saline 
      solution (150 mL of 1.4-4.6% NaCl) twice a day for 6 to 12 days. A daily fluid 
      oral intake of 1000 mL and previous cardiac therapy were maintained. Clinical 
      signs and symptoms of CHF, such as dyspnea, edema and weakness, improved, as did 
      severity of illness as defined by NYHA class. The infusion was well tolerated. 
      After a 12-month follow-up, 24 patients (80%) were alive and in the NYHA class 
      assigned on discharge from the hospital. This therapeutic combination is 
      effective and well tolerated and should represent an innovative approach to the 
      management of refractory CHF.
FAU - Paterna, S
AU  - Paterna S
AD  - Department of Internal Medicine, University of Palermo, Italy.
FAU - Parrinello, G
AU  - Parrinello G
FAU - Amato, P
AU  - Amato P
FAU - Dominguez, L
AU  - Dominguez L
FAU - Pinto, A
AU  - Pinto A
FAU - Maniscalchi, T
AU  - Maniscalchi T
FAU - Cardinale, A
AU  - Cardinale A
FAU - Licata, A
AU  - Licata A
FAU - Amato, V
AU  - Amato V
FAU - Licata, G
AU  - Licata G
FAU - Di Pasquale, P
AU  - Di Pasquale P
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Adv Ther
JT  - Advances in therapy
JID - 8611864
RN  - 0 (Diuretics)
RN  - 0 (Saline Solution, Hypertonic)
RN  - 7LXU5N7ZO5 (Furosemide)
MH  - Aged
MH  - Aged, 80 and over
MH  - Diuretics/*therapeutic use
MH  - Female
MH  - Furosemide/*therapeutic use
MH  - Heart Failure/*drug therapy/mortality
MH  - Humans
MH  - Infusions, Intravenous
MH  - Italy/epidemiology
MH  - Male
MH  - Saline Solution, Hypertonic/*therapeutic use
MH  - Statistics, Nonparametric
MH  - Survival Rate
EDAT- 2000/08/01 00:00
MHDA- 2000/08/01 00:01
CRDT- 2000/08/01 00:00
PHST- 2000/08/01 00:00 [pubmed]
PHST- 2000/08/01 00:01 [medline]
PHST- 2000/08/01 00:00 [entrez]
AID - 179 [pii]
PST - ppublish
SO  - Adv Ther. 1999 Sep-Oct;16(5):219-28.