PMID- 10921319
OWN - NLM
STAT- MEDLINE
DCOM- 20001019
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 58
IP  - 7
DP  - 2000 Jul
TI  - [Multiple endocrine neoplasia 1 (MEN 1)].
PG  - 1434-6
AB  - Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant familial 
      cancer syndrome characterized by tumors in parathyroids, enteropancreatic 
      endocrine tissues, and anterior pituitary. In 1997, the MEN 1 gene was identified 
      and cloned. It is on chromosome 11q13 and has 10 exons. It encodes a 610 amino 
      acid protein called MENIN. However, many different germline mutations in MEN 1 
      families have reported, there were no hotspot of mutation. The correlation 
      between MEN 1 mutation and clinical datas has not been established yet. Recently, 
      the possible function of MENIN protein has reported. The identification of MEN 1 
      mutation by employing DNA test, will facilitate early diagnosis and treatment.
FAU - Kameyama, K
AU  - Kameyama K
AD  - Division of Diagnostic Pathology, Keio University Hospital.
FAU - Takami, H
AU  - Takami H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Chromosomes, Human, Pair 11
MH  - Gastrinoma/diagnosis/genetics
MH  - Germ-Line Mutation
MH  - Humans
MH  - Insulinoma/diagnosis/genetics
MH  - *Multiple Endocrine Neoplasia Type 2a/diagnosis/genetics
MH  - Neoplasm Proteins/genetics
MH  - Pancreatic Neoplasms/diagnosis/genetics
MH  - *Proto-Oncogene Proteins
RF  - 11
EDAT- 2000/08/02 11:00
MHDA- 2000/10/21 11:01
CRDT- 2000/08/02 11:00
PHST- 2000/08/02 11:00 [pubmed]
PHST- 2000/10/21 11:01 [medline]
PHST- 2000/08/02 11:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 2000 Jul;58(7):1434-6.