PMID- 10921719
OWN - NLM
STAT- MEDLINE
DCOM- 20000822
LR  - 20220321
IS  - 0003-4975 (Print)
IS  - 0003-4975 (Linking)
VI  - 70
IP  - 1
DP  - 2000 Jul
TI  - Prognostic factors in neuroendocrine lung tumors: a Spanish Multicenter Study. 
      Spanish Multicenter Study of Neuroendocrine Tumors of the Lung of the Spanish 
      Society of Pneumonology and Thoracic Surgery (EMETNE-SEPAR).
PG  - 258-63
AB  - BACKGROUND: This study examines the experience of the Spanish Multicenter Study 
      of Neuroendocrine Tumors of the Lung through the clinical data and behavior of 
      patients treated for this pathologic process. METHODS: From 1980 to 1997, 361 
      cases of neuroendocrine carcinomas (NEC) were treated surgically. Patients were 
      enrolled in a protocol using the pathologic and follow-up reports. According to 
      Dreslers' criteria, the cases were segregated into grade 1 (typical carcinoid), 
      grade 2 (atypical carcinoid), grade 3 large cell type, and grade 3 small cell 
      type. Several variables were reviewed in all patients. Statistical analysis was 
      performed to determine whether clinical characteristics and differentiation were 
      associated with significant differences in the prognosis. RESULTS: A total of 261 
      cases of NEC were identified with grade 1, 43 with grade 2, and with grade 3: 22 
      of large and 35 of small cells. Five-year survival for different grades was as 
      follows: grade 1, 96%; 2, 72%; 3 large cell type, 21%; and 3 small cell type, 
      14%. When a comparative analysis between typical and atypical carcinoids was 
      performed a significant difference for mean age, tumor size, nodal metastases, 
      and recurrence was observed. However, female sex, nodal metastases, and 
      recurrence rate differed between atypical carcinoids and grade 3 NEC of large 
      cells. A difference in recurrence rate was found between patients with both types 
      of grade 3 NEC. CONCLUSIONS: The progressive deterioration of tumor organization 
      highlights that neuroendocrine tumors constitute a continuous spectrum. A careful 
      observation of pathologic findings is necessary to individualize their prognostic 
      factors.
FAU - Garcia-Yuste, M
AU  - Garcia-Yuste M
AD  - Services of Thoracic Surgery and Pathology, University Hospital, Valladolid, 
      Spain.
FAU - Matilla, J M
AU  - Matilla JM
FAU - Alvarez-Gago, T
AU  - Alvarez-Gago T
FAU - Duque, J L
AU  - Duque JL
FAU - Heras, F
AU  - Heras F
FAU - Cerezal, L J
AU  - Cerezal LJ
FAU - Ramos, G
AU  - Ramos G
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoid Tumor/mortality/pathology/surgery
MH  - Carcinoma, Neuroendocrine/mortality/pathology/surgery
MH  - Carcinoma, Small Cell/mortality/pathology/surgery
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/mortality/pathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Neuroendocrine Tumors/mortality/pathology/*surgery
MH  - Prognosis
MH  - Spain
MH  - Survival Rate
EDAT- 2000/08/02 11:00
MHDA- 2000/08/29 11:01
CRDT- 2000/08/02 11:00
PHST- 2000/08/02 11:00 [pubmed]
PHST- 2000/08/29 11:01 [medline]
PHST- 2000/08/02 11:00 [entrez]
AID - S0003497500013692 [pii]
AID - 10.1016/s0003-4975(00)01369-2 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2000 Jul;70(1):258-63. doi: 10.1016/s0003-4975(00)01369-2.