PMID- 10923142
OWN - NLM
STAT- MEDLINE
DCOM- 20000822
LR  - 20220309
IS  - 0755-4982 (Print)
IS  - 0755-4982 (Linking)
VI  - 29
IP  - 23
DP  - 2000 Jul 1
TI  - [Subacute cutaneous lupus erythematosus].
PG  - 1311-6
AB  - SKIN LESIONS: The concept that patients with subacute cutaneous lupus 
      erythematosus (SCLE) skin lesions represent a distinct lupus erythematosus subset 
      was proposed in 1979 by Sontheimer and supported by many studies. Skin lesions 
      are papulo-squamous, psoriasiform or annular. Photosensitivity is a common 
      complaint and photo-reproduction is significantly frequent in these patients. 
      They persist for weeks or months and typically heal without atrophy or scarring 
      with hyperpigmentation or more often hypopigmentation. SYSTEMIC INVOLVEMENT: 
      Systemic disease is generally quite mild and the prognostic is usually 
      favourable. High-titer, precipitating antibodies to Ro/SSA and HLA DR2 and/or HLA 
      DR3 are strongly associated with SCLE. In some observations, the relation-ship 
      between SCLE and drugs has been recognized. TREATMENT: Antimalarial agents are 
      first line systemic treatment. Other therapies, including Thalidomide are helpful 
      for patients with resistant disease. The pathomechanisms of photosensitive SCLE 
      involved antigens Ro/SSA, epidermal and dermal cytokines, intercellular adhesion 
      molecules, mononuclear cells.
FAU - Doutre, M S
AU  - Doutre MS
AD  - Service de Dermatologie, Hopital du Haut-Leveque, Pessac.
FAU - Beylot-Barry, M
AU  - Beylot-Barry M
FAU - Beylot, C
AU  - Beylot C
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Lupus erythemateux cutane subaigu.
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
RN  - 0 (Biomarkers)
SB  - IM
MH  - Acute Disease
MH  - Biomarkers/blood
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/complications/*diagnosis/physiopathology/*therapy
MH  - Prognosis
RF  - 50
EDAT- 2000/08/03 11:00
MHDA- 2000/08/29 11:01
CRDT- 2000/08/03 11:00
PHST- 2000/08/03 11:00 [pubmed]
PHST- 2000/08/29 11:01 [medline]
PHST- 2000/08/03 11:00 [entrez]
PST - ppublish
SO  - Presse Med. 2000 Jul 1;29(23):1311-6.