PMID- 10924791
OWN - NLM
STAT- MEDLINE
DCOM- 20001011
LR  - 20190728
IS  - 0264-410X (Print)
IS  - 0264-410X (Linking)
VI  - 19
IP  - 1
DP  - 2000 Aug 15
TI  - Interleukin-18 modulates immune responses induced by HIV-1 Nef DNA prime/protein 
      boost vaccine.
PG  - 95-102
AB  - Many different HIV-1 vaccine strategies have been developed, but as yet none has 
      been completely successful. Promising results from combined DNA prime/protein 
      boost vaccines have been reported. Specific immune responses generated by DNA 
      vaccines can be modulated by the co-delivery of genes coding for cytokines. In 
      this study, we have used the intradermal route by needle injection of a plasmid 
      coding for the HIV-1 Nef accessory protein. We show that DNA prime/protein boost 
      vaccine combinations increase the humoral and cellular immune responses against 
      HIV-1 Nef and that the co-injection of DNA encoding Interleukin-18 (IL-18) 
      modulates the specific immune response towards a Th1 type.
FAU - Billaut-Mulot, O
AU  - Billaut-Mulot O
AD  - Unite Inserm 167, Pasteur de Lille, Lille, France.
FAU - Idziorek, T
AU  - Idziorek T
FAU - Ban, E
AU  - Ban E
FAU - Kremer, L
AU  - Kremer L
FAU - Dupre, L
AU  - Dupre L
FAU - Loyens, M
AU  - Loyens M
FAU - Riveau, G
AU  - Riveau G
FAU - Locht, C
AU  - Locht C
FAU - Capron, A
AU  - Capron A
FAU - Bahr, G M
AU  - Bahr GM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (AIDS Vaccines)
RN  - 0 (DNA, Viral)
RN  - 0 (Gene Products, nef)
RN  - 0 (Interleukin-18)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Vaccines, DNA)
RN  - 0 (Viral Proteins)
RN  - 0 (nef Gene Products, Human Immunodeficiency Virus)
SB  - IM
MH  - AIDS Vaccines/*administration & dosage/immunology
MH  - Animals
MH  - Antibody Formation/drug effects
MH  - DNA, Viral/*administration & dosage/immunology
MH  - Female
MH  - Gene Products, nef/administration & dosage/biosynthesis/genetics/*immunology
MH  - HIV-1/genetics/*immunology
MH  - Immunity, Cellular/drug effects
MH  - Immunization, Secondary
MH  - Interleukin-18/genetics/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plasmids/genetics
MH  - Recombinant Proteins/administration & dosage/immunology
MH  - Vaccines, DNA/*administration & dosage/immunology
MH  - Viral Proteins/administration & dosage/immunology
MH  - nef Gene Products, Human Immunodeficiency Virus
EDAT- 2000/08/05 11:00
MHDA- 2000/10/14 11:01
CRDT- 2000/08/05 11:00
PHST- 2000/08/05 11:00 [pubmed]
PHST- 2000/10/14 11:01 [medline]
PHST- 2000/08/05 11:00 [entrez]
AID - S0264-410X(00)00157-2 [pii]
AID - 10.1016/s0264-410x(00)00157-2 [doi]
PST - ppublish
SO  - Vaccine. 2000 Aug 15;19(1):95-102. doi: 10.1016/s0264-410x(00)00157-2.