PMID- 10926654
OWN - NLM
STAT- MEDLINE
DCOM- 20000915
LR  - 20220318
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 89
IP  - 2
DP  - 2000 Aug
TI  - Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to 
      hypoxia in humans.
PG  - 680-6
AB  - In cell culture, hypoxia stabilizes a transcriptional complex called 
      hypoxia-inducible factor-1 (HIF-1) that increases erythropoietin (Epo) formation. 
      One hallmark of HIF-1 responses is that they can be induced by iron chelation. 
      The first aim of this study was to examine whether an infusion of desferrioxamine 
      (DFO) increased serum Epo in humans. If so, this might provide a paradigm for 
      identifying other HIF-1 responses in humans. Consequently a second aim was to 
      determine whether an infusion of DFO would mimic prolonged hypoxia and increase 
      the acute hypoxic ventilatory response (AHVR). Sixteen volunteers undertook two 
      protocols: 1) continuous infusion of DFO over 8 h and 2) control. Epo and AHVR 
      were measured at fixed times during and after the protocols. The results show 
      that 1) compared with control, Epo increased in most subjects at 8 h [52.8 +/- 
      57.7 vs. 6.9 +/- 2.5 (SD) mIU/ml, for DFO = 4 g/70 kg body wt, P < 0.05] and 12 h 
      (63.7 +/- 76.3 vs. 7.3 +/- 2.5 mIU/ml, P < 0.001) after the start of DFO 
      administration and 2) DFO had no significant effect on AHVR. We conclude that, 
      whereas infusions of DFO mimic hypoxia by increasing Epo, they do not mimic 
      prolonged hypoxia by augmenting AHVR.
FAU - Ren, X
AU  - Ren X
AD  - University Laboratory of Physiology, University of Oxford, United Kingdom.
FAU - Dorrington, K L
AU  - Dorrington KL
FAU - Maxwell, P H
AU  - Maxwell PH
FAU - Robbins, P A
AU  - Robbins PA
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 11096-26-7 (Erythropoietin)
RN  - 142M471B3J (Carbon Dioxide)
RN  - J06Y7MXW4D (Deferoxamine)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Carbon Dioxide/blood
MH  - Carotid Body/physiology
MH  - Deferoxamine/administration & dosage/*pharmacology
MH  - Erythropoietin/*blood
MH  - Female
MH  - Humans
MH  - Hypoxia/*physiopathology
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Respiratory Mechanics/*physiology
EDAT- 2000/08/05 11:00
MHDA- 2000/09/23 11:01
CRDT- 2000/08/05 11:00
PHST- 2000/08/05 11:00 [pubmed]
PHST- 2000/09/23 11:01 [medline]
PHST- 2000/08/05 11:00 [entrez]
AID - 10.1152/jappl.2000.89.2.680 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2000 Aug;89(2):680-6. doi: 10.1152/jappl.2000.89.2.680.