PMID- 10928464
OWN - NLM
STAT- MEDLINE
DCOM- 20010202
LR  - 20041117
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 84
IP  - 1
DP  - 2000 Jul
TI  - Nomograms for the administration of unfractionated heparin in the initial 
      treatment of acute thromboembolism--an overview.
PG  - 22-6
AB  - Despite the availability of low-molecular-weight heparins, unfractionated heparin 
      (UFH) still remains the drug of choice for the initial treatment of acute venous 
      thromboembolism in many countries. When appropriately employed, UFH treatment 
      results in a degree of efficacy and safety that is fully comparable with that 
      obtained with the use of heparin derivatives. The use of nomograms for the 
      intravenous or subcutaneous administration of UFH assures that virtually all 
      patients will promptly achieve adequate levels of anticoagulation, thus 
      decreasing the likelihood of recurrent venous thromboembolism without extra 
      bleeding-risk. In this article we reviewed clinical studies on the implementation 
      and validation of UFH dosing nomograms, and attempted a quantitative analysis of 
      their performance. According to the results of our analysis, a statistically 
      significantly higher proportion of patients treated on the basis of a nomogram 
      reached a therapeutic anticoagulant level within 24 h of treatment, as compared 
      to patients treated following the standard practice (odds ratio, 3.6; 95% CI, 2.6 
      to 4.9). The rate of recurrent thromboembolic events was significantly lower for 
      patients treated according to a nomogram (odds ratio, 0.3; 95% CI, 0.1 to 0.8), 
      while no significant differences in terms of either major or minor bleedings were 
      detected between nomogram patients and controls.
FAU - Bernardi, E
AU  - Bernardi E
AD  - Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, 
      University of Padua, Italy.
FAU - Piccioli, A
AU  - Piccioli A
FAU - Oliboni, G
AU  - Oliboni G
FAU - Zuin, R
AU  - Zuin R
FAU - Girolami, A
AU  - Girolami A
FAU - Prandoni, P
AU  - Prandoni P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
CIN - Thromb Haemost. 2001 Mar;85(3):565. PMID: 11307835
MH  - *Algorithms
MH  - Anticoagulants/*administration & dosage/adverse effects/therapeutic use
MH  - Body Weight
MH  - Decision Making
MH  - Dose-Response Relationship, Drug
MH  - Drug Therapy/standards
MH  - Hemorrhage/chemically induced/epidemiology
MH  - Heparin/*administration & dosage/adverse effects/therapeutic use
MH  - Humans
MH  - Injections, Intravenous
MH  - Injections, Subcutaneous
MH  - Odds Ratio
MH  - Partial Thromboplastin Time
MH  - Risk
MH  - Thromboembolism/*drug therapy
RF  - 33
EDAT- 2000/08/06 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/08/06 11:00
PHST- 2000/08/06 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/08/06 11:00 [entrez]
AID - 00070022 [pii]
PST - ppublish
SO  - Thromb Haemost. 2000 Jul;84(1):22-6.