PMID- 10929263
OWN - NLM
STAT- MEDLINE
DCOM- 20001010
LR  - 20161124
IS  - 0914-5087 (Print)
IS  - 0914-5087 (Linking)
VI  - 36
IP  - 1
DP  - 2000 Jul
TI  - [Prediction of cardiac sympathetic nerve activity and cardiac functional outcome 
      after treatment in patients with dilated cardiomyopathy: examination using 
      dobutamine gated blood pool scintigraphy].
PG  - 29-35
AB  - OBJECTIVES: This study evaluated whether dobutamine gated blood pool scintigraphy 
      can predict improvement of cardiac sympathetic nerve activity and cardiac 
      function. METHODS: Sixteen patients(10 men and 6 women, mean age 59 +/- 13 years) 
      with dilated cardiomyopathy underwent dobutamine gated blood pool scintigraphy to 
      measure left ventricular ejection fraction (LVEF) using tracer at 0, 5, 10 and 15 
      micrograms/kg/min before treatment. Patients were divided into good responders 
      (LVEF increase > or = 15%) 8 patients(GR Group) and poor responders(LVEF increase 
      < 15%) 8 patients (PR Group) after treatment with beta-blocker or amiodarone with 
      a background treatment of digitalis, diuretics and angiotensin converting enzyme 
      inhibitor. I-123 metaiodobenzylguanidine(MIBG) imaging to evaluate cardiac 
      sympathetic nerve activity and echocardiography were performed before and at one 
      year after treatment. MIBG imaging was obtained 4 hours after tracer injection, 
      and the heart/mediastinum count ratio(H/M ratio) calculated from the anterior 
      planar image and the total defect score(TDS) from the single photon emission 
      computed tomography image. LVEF and left ventricular endo-diastolic dimension 
      (LVDd) were measured by echocardiography and New York Heart Association(NYHA) 
      functional class was evaluated. RESULTS: The GR Group showed TDS decreased from 
      28 +/- 6 to 17 +/- 12(p < 0.05), H/M ratio increased from 1.79 +/- 0.26 to 2.07 
      +/- 0.32(p < 0.05), LVEF increased from 29 +/- 8% to 48 +/- 10%(p < 0.01), and 
      LVDd decreased from 65 +/- 4 mm to 58 +/- 5 mm(p < 0.05). In contrast, the PR 
      Group showed no significant changes in TDS, H/M ratio, LVEF and LVDd. NYHA 
      functional class improved in both groups. The improvement was better in the GR 
      Group than in the PR Group. CONCLUSIONS: Dobutamine gated blood pool scintigraphy 
      is useful to predict the improvement of the cardiac sympathetic nerve activity 
      and cardiac function, and symptoms after treatment in patients with dilated 
      cardiomyopathy.
FAU - Kasama, S
AU  - Kasama S
AD  - Second Department of Internal Medicine, Gunma University School of Medicine.
FAU - Toyama, T
AU  - Toyama T
FAU - Hoshizaki, H
AU  - Hoshizaki H
FAU - Oshima, S
AU  - Oshima S
FAU - Taniguchi, K
AU  - Taniguchi K
FAU - Iwasaki, T
AU  - Iwasaki T
FAU - Suzuki, T
AU  - Suzuki T
FAU - Nagai, R
AU  - Nagai R
LA  - jpn
PT  - Journal Article
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Digitalis Glycosides)
RN  - 0 (Diuretics)
RN  - 0 (Vasodilator Agents)
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
RN  - 3S12J47372 (Dobutamine)
RN  - N3RQ532IUT (Amiodarone)
SB  - IM
MH  - 3-Iodobenzylguanidine
MH  - Adrenergic beta-Antagonists/therapeutic use
MH  - Amiodarone/therapeutic use
MH  - Angiotensin-Converting Enzyme Inhibitors/therapeutic use
MH  - Cardiomyopathy, Dilated/diagnostic imaging/drug therapy/*physiopathology
MH  - *Cardiotonic Agents/therapeutic use
MH  - Digitalis Glycosides/therapeutic use
MH  - Diuretics/therapeutic use
MH  - *Dobutamine
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stroke Volume/physiology
MH  - Sympathetic Nervous System/*physiopathology
MH  - *Tomography, Emission-Computed, Single-Photon
MH  - Vasodilator Agents/therapeutic use
MH  - Ventricular Function, Left/*physiology
EDAT- 2000/08/10 11:00
MHDA- 2000/10/14 11:01
CRDT- 2000/08/10 11:00
PHST- 2000/08/10 11:00 [pubmed]
PHST- 2000/10/14 11:01 [medline]
PHST- 2000/08/10 11:00 [entrez]
PST - ppublish
SO  - J Cardiol. 2000 Jul;36(1):29-35.