PMID- 10929427
OWN - NLM
STAT- MEDLINE
DCOM- 20001207
LR  - 20190915
IS  - 0300-5623 (Print)
IS  - 0300-5623 (Linking)
VI  - 28
IP  - 3
DP  - 2000 Jun
TI  - Aberration of chromosomes 8 and 11 in bladder cancer as detected by fluorescence 
      in situ hybridization.
PG  - 185-90
AB  - Although a bladder cancer-specific abnormality in chromosomes or genes has not 
      been reported, chromosomal regions that tend to become abnormal have been 
      recognized. In this study, we investigated abnormalities in chromosomes 8 and 11. 
      There were 27 patients with bladder cancer, 16 males and 11 females, who 
      participated in this study. Abnormalities in chromosomes 8 and 11 were 
      investigated by the fluorescence in situ hybridization (FISH) method. Probes used 
      in this study were chromosome 8 alpha-satellite and chromosome 11 alpha-satellite 
      (Oncor Co.). Of 27 cases, 15 cases were positive for chromosome 8 (55.6%) and ten 
      cases were positive for chromosome 11 (37.0%). Since the FISH method detects 
      chromosomal abnormality by the number of signals generated in cancer cells, this 
      method is objective and simple and thus may be applicable in clinical practice.
FAU - Awata, S
AU  - Awata S
AD  - Department of Urology, Kousei Hospital, Aichi Ken, Japan.
FAU - Sakagami, H
AU  - Sakagami H
FAU - Tozawa, K
AU  - Tozawa K
FAU - Sasaki, S
AU  - Sasaki S
FAU - Ueda, K
AU  - Ueda K
FAU - Kohri, K
AU  - Kohri K
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Urol Res
JT  - Urological research
JID - 0364311
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Small Cell/*genetics
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Genes, myc
MH  - Genes, ras
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Urinary Bladder Neoplasms/*genetics
EDAT- 2000/08/10 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/10 11:00
PHST- 2000/08/10 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/10 11:00 [entrez]
AID - 10.1007/s002409900077 [doi]
PST - ppublish
SO  - Urol Res. 2000 Jun;28(3):185-90. doi: 10.1007/s002409900077.