PMID- 10929648
OWN - NLM
STAT- MEDLINE
DCOM- 20000921
LR  - 20071115
IS  - 0044-409X (Print)
IS  - 0044-409X (Linking)
VI  - 125 Suppl 1
DP  - 2000
TI  - [Role of chemokines in human skin wound healing].
PG  - 56-9
AB  - The healing process of skin wounds is regulated by growth factors which stimulate 
      proliferation of resident cells and their synthesis of extra cellular 
      matrixcomponents. Different leukocyte subtypes (neutrophils, macrophages, 
      lymphocytes and mast cells) participate in wound healing not only as 
      immunological effector cells but also as an important source of inflammatory and 
      growth promoting cytokines. Rapid recruitment of leukocytes and their positioning 
      is tightly regulated by a temporally and spatially changing set of chemokines. 
      Whereas expression of IL-8 and GRO (growth related oncogene) direct early 
      neutrophil recruitment, migration of macrophages is stimulated by MCP-1 (monocyte 
      chemoattractant protein-1) and later, lymphocytes are attracted by IP-10 
      (gamma-interferon inducible protein-10) and Mig (monokine induced by 
      interferon-gamma). Since chemokines as IL-8 and GRO also stimulate angiogenesis 
      and keratinocyte proliferation, they integrate the inflammatory events with the 
      reparative processes and are potential candidates in the search of wound healing 
      agents.
FAU - Gillitzer, R
AU  - Gillitzer R
AD  - Klinik fur Haut- und Geschlechtskrankheiten, Universitatsklinikum Wurzburg. 
      gillitzer-r.derma@mail.uni-wuerzburg.de
FAU - Toksoy, A
AU  - Toksoy A
FAU - Voss, A
AU  - Voss A
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Die Rolle der Chemokine bei der Wundheilung der menschlichen Haut.
PL  - Germany
TA  - Zentralbl Chir
JT  - Zentralblatt fur Chirurgie
JID - 0413645
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Chemokines)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Interleukin-8)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - B-Lymphocytes/physiology
MH  - Chemokine CXCL10
MH  - Chemokines/genetics/*physiology
MH  - Chemokines, CXC/physiology
MH  - Humans
MH  - Interleukin-8/genetics/physiology
MH  - Macrophages/physiology
MH  - Monocytes/physiology
MH  - Neovascularization, Physiologic
MH  - Neutrophils/physiology
MH  - RNA, Messenger/genetics
MH  - Receptors, Chemokine/physiology
MH  - Skin/*injuries
MH  - T-Lymphocytes/physiology
MH  - Wound Healing/*physiology
EDAT- 2000/08/10 11:00
MHDA- 2000/09/23 11:01
CRDT- 2000/08/10 11:00
PHST- 2000/08/10 11:00 [pubmed]
PHST- 2000/09/23 11:01 [medline]
PHST- 2000/08/10 11:00 [entrez]
PST - ppublish
SO  - Zentralbl Chir. 2000;125 Suppl 1:56-9.