PMID- 10930656
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210722
IS  - 1879-1514 (Electronic)
IS  - 0166-445X (Linking)
VI  - 50
IP  - 1-2
DP  - 2000 Aug 1
TI  - Hepatic microsomal desulfuration and dearylation of chlorpyrifos and parathion in 
      fingerling channel catfish: lack of effect from Aroclor 1254.
PG  - 141-151
AB  - Channel catfish were treated intraperitoneally with 100 mg Aroclor 1254/kg body 
      weight and sacrificed at 96 h to observe the effects of this cytochrome P450 1A 
      (CYP1A) inducer on chlorpyrifos and parathion metabolism. In the initial 
      experiment, hepatic microsomal ethoxyresorufin-O-deethylase (EROD) activity of 
      the Aroclor-treated fish was significantly induced but no effects on 
      desulfuration or dearylation of chlorpyrifos or parathion were evident. In the 
      second experiment, Aroclor 1254 did not alter total hepatic microsomal P450s 
      content, but significantly induced hepatic EROD and CYP1A. There were no evident 
      effects to other hepatic CYP isoforms recognized by anti-trout CYP2K1, CYP2M1 and 
      CYP3A27. These experiments indicate that Aroclor 1254 did not induce the P450s 
      responsible for metabolism of the phosphorothionate insecticides.
FAU - Straus, David L
AU  - Straus DL
AD  - Center for Environmental Health Sciences, College of Veterinary Medicine, Box 
      9825, Mississippi State University, 39762-9825, Mississippi State, MS, USA
FAU - Schlenk, Daniel
AU  - Schlenk D
FAU - Chambers, Janice E
AU  - Chambers JE
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Aquat Toxicol
JT  - Aquatic toxicology (Amsterdam, Netherlands)
JID - 8500246
EDAT- 2000/08/10 00:00
MHDA- 2000/08/10 00:01
CRDT- 2000/08/10 00:00
PHST- 2000/08/10 00:00 [pubmed]
PHST- 2000/08/10 00:01 [medline]
PHST- 2000/08/10 00:00 [entrez]
AID - S0166445X99000880 [pii]
AID - 10.1016/s0166-445x(99)00088-0 [doi]
PST - ppublish
SO  - Aquat Toxicol. 2000 Aug 1;50(1-2):141-151. doi: 10.1016/s0166-445x(99)00088-0.