PMID- 10933620
OWN - NLM
STAT- MEDLINE
DCOM- 20001122
LR  - 20171116
IS  - 0889-2229 (Print)
IS  - 0889-2229 (Linking)
VI  - 16
IP  - 11
DP  - 2000 Jul 20
TI  - The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by 
      macaque and human skin- and blood-derived dendritic cells.
PG  - 1055-9
AB  - Dendritic cells (DCs) have been shown to be important in the replication of human 
      and simian immunodeficiency viruses (HIV and SIV, respectively) in vivo and in 
      vitro. DCs express CD4 and several chemokine receptors, such as CCR5 and CXCR4, 
      which are important for viral entry. In vivo, DCs are abundant at body surfaces, 
      where they might be one of the first cells that encounter naturally transmitted 
      virus. Furthermore, DCs pulsed with HIV or SIV in vitro can efficiently transmit 
      virus to T cells, thereby propagating vigorous viral replication. Reports have 
      implicated Bonzo/STRL33/TYMSTR to be an additional alternative coreceptor for HIV 
      and especially SIV infection. However, at present there are no reports regarding 
      the expression of Bonzo/STRL33/TYMSTR by human or macaque DCs. Here we 
      demonstrate the presence of Bonzo/STRL33/TYMSTR transcripts in rhesus macaque and 
      human skin-derived DCs, in immature and mature blood monocyte-derived DCs, and in 
      T cells from both skin and blood. Therefore, Bonzo/STRL33/TYMSTR is expressed in 
      DCs and T cells that can play a role in the transmission of immunodeficiency 
      viruses.
FAU - Ignatius, R
AU  - Ignatius R
AD  - Laboratory of Cellular Physiology and Immunology, Rockefeller University, New 
      York, New York 10021, USA.
FAU - Wei, Y
AU  - Wei Y
FAU - Beaulieu, S
AU  - Beaulieu S
FAU - Gettie, A
AU  - Gettie A
FAU - Steinman, R M
AU  - Steinman RM
FAU - Pope, M
AU  - Pope M
FAU - Mojsov, S
AU  - Mojsov S
LA  - eng
GR  - AI 40045/AI/NIAID NIH HHS/United States
GR  - AI 40877/AI/NIAID NIH HHS/United States
GR  - AI 44335/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
RN  - 0 (CXCR6 protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, CCR5)
RN  - 0 (Receptors, CXCR6)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, Virus)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Dendritic Cells/*metabolism
MH  - Humans
MH  - Macaca mulatta
MH  - Monocytes/*cytology/metabolism
MH  - RNA, Messenger/metabolism
MH  - Receptors, CCR5/metabolism
MH  - Receptors, CXCR6
MH  - Receptors, Chemokine
MH  - Receptors, Cytokine/*metabolism
MH  - *Receptors, G-Protein-Coupled
MH  - Receptors, Virus/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Skin/*cytology/metabolism
MH  - T-Lymphocytes/metabolism
EDAT- 2000/08/10 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/10 11:00
PHST- 2000/08/10 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/10 11:00 [entrez]
AID - 10.1089/08892220050075318 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2000 Jul 20;16(11):1055-9. doi: 
      10.1089/08892220050075318.