PMID- 10936492
OWN - NLM
STAT- MEDLINE
DCOM- 20001017
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 401
IP  - 3
DP  - 2000 Aug 11
TI  - Atrial natriuretic peptide modulates N-methyl-D-aspartate-induced 
      hyperexcitability in ethanol-dependent mice.
PG  - 343-7
AB  - The role of central nervous atrial natriuretic peptide was investigated for 
      behavioral hyperexcitability in alcohol-dependent mice. Mice were made tolerant 
      to and dependent on ethanol with an ethanol-liquid diet for 14 days. Five hours 
      after withdrawal from ethanol, withdrawal symptoms were analyzed by scoring 
      handling-induced convulsions. N-methyl-D-aspartate (NMDA) induced behavioral 
      seizures in a dose-dependent manner, an effect which was more intensive during 
      the ethanol withdrawal period than in alcohol-naive animals. 
      Intracerebroventricular (i.c.v.) injections of alpha-atrial natriuretic peptide 
      (atrial natriuretic peptide) dose-dependently inhibited, whereas injection of an 
      antiserum against atrial natriuretic peptide potentiated, the seizure-inducing 
      effect of NMDA in ethanol-dependent mice. The main conclusion is that central 
      nervous atrial natriuretic peptide plays a modulatory role in behavioral 
      hyperexcitability during alcohol withdrawal.
FAU - Kovacs, G L
AU  - Kovacs GL
AD  - Central Laboratory, Markusovszky Teaching Hospital, Markusovszky St. 3., H-9701, 
      Szombathely, Hungary. glkovacs@mail.matav.hu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Immune Sera)
RN  - 3K9958V90M (Ethanol)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Animals
MH  - Atrial Natriuretic Factor/immunology/*pharmacology
MH  - Behavior, Animal/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drug Synergism
MH  - Ethanol/*pharmacology
MH  - Immune Sera/adverse effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - N-Methylaspartate/*adverse effects
MH  - Seizures/chemically induced/*prevention & control
MH  - *Substance-Related Disorders
EDAT- 2000/08/11 11:00
MHDA- 2000/10/21 11:01
CRDT- 2000/08/11 11:00
PHST- 2000/08/11 11:00 [pubmed]
PHST- 2000/10/21 11:01 [medline]
PHST- 2000/08/11 11:00 [entrez]
AID - S001429990000474X [pii]
AID - 10.1016/s0014-2999(00)00474-x [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2000 Aug 11;401(3):343-7. doi: 10.1016/s0014-2999(00)00474-x.