PMID- 10936689
OWN - NLM
STAT- MEDLINE
DCOM- 20000921
LR  - 20220408
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 290
IP  - 2
DP  - 2000 Aug 25
TI  - Acute stress decreases serotonin transporter mRNA in the raphe pontis but not in 
      other raphe nuclei of the rat.
PG  - 109-12
AB  - In addition to elevated corticosterone levels, stress produces structural changes 
      and neuronal damage especially in the hippocampus. In this line it has been 
      shown, that in rats single or repeated immobilisation markedly reduces 
      brain-derived neurotrophic factor (BDNF) mRNA levels in the hippocampal 
      formation. Since this neurotrophin also controls the efficacy of serotonergic 
      neurotransmission, the aim of the current study was to investigate the effect of 
      acute immobilization stress on the expression of serotonin transporter (SERT) 
      mRNA in the raphe nuclei as a parameter of serotonergic innervation. We have 
      examined the expression of SERT mRNA and of BDNF mRNA in rats upon acute 
      immobilisation by quantitative in situ hybridisation with a (35)S-labelled 
      oligonucleotide probe. Elevated corticosterone levels in stressed animals 
      confirmed as internal controls the effect of stress under our conditions. Acute 
      stress led to a significant decrease of BDNF mRNA in the hippocampus and of SERT 
      mRNA in the raphe pontis, but not in other raphe nuclei investigated. These data 
      provide evidence for fast interactions between neurotrophins, corticosterone and 
      serotonergic neurotransmission under stress conditions.
FAU - Vollmayr, B
AU  - Vollmayr B
AD  - Department of Biochemistry, Central Institute for Mental Health, 68159, Mannheim, 
      Germany.
FAU - Keck, S
AU  - Keck S
FAU - Henn, F A
AU  - Henn FA
FAU - Schloss, P
AU  - Schloss P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Slc6a4 protein, rat)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Carrier Proteins/*genetics
MH  - Corticosterone/blood
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - *Membrane Transport Proteins
MH  - *Nerve Tissue Proteins
MH  - Neurons/metabolism/pathology
MH  - RNA, Messenger/metabolism
MH  - Raphe Nuclei/*metabolism/pathology/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin Plasma Membrane Transport Proteins
MH  - Stress, Physiological/pathology/*physiopathology
EDAT- 2000/08/11 11:00
MHDA- 2000/09/23 11:01
CRDT- 2000/08/11 11:00
PHST- 2000/08/11 11:00 [pubmed]
PHST- 2000/09/23 11:01 [medline]
PHST- 2000/08/11 11:00 [entrez]
AID - S0304-3940(00)01346-X [pii]
AID - 10.1016/s0304-3940(00)01346-x [doi]
PST - ppublish
SO  - Neurosci Lett. 2000 Aug 25;290(2):109-12. doi: 10.1016/s0304-3940(00)01346-x.