PMID- 10938578
OWN - NLM
STAT- MEDLINE
DCOM- 20000914
LR  - 20191210
IS  - 1025-3890 (Print)
IS  - 1025-3890 (Linking)
VI  - 3
IP  - 2
DP  - 1999 Dec
TI  - Corticosterone effects on BDNF mRNA expression in the rat hippocampus during 
      morris water maze training.
PG  - 173-83
AB  - Corticosterone and Brain-Derived Neurotrophic Factor (BDNF) have both been shown 
      to be involved in spatial memory formation in rats. In the present study we have 
      investigated the effect of corticosterone on hippocampal BDNF mRNA expression 
      after training in the Morris water maze in young adult Wistar rats. Therefore, we 
      first studied BDNF mRNA levels in the hippocampus in relation to corticosterone 
      levels at several time points after 4 training trials in the Morris water maze. 
      Corticosterone levels were significantly increased after this procedure, and 
      hippocampal BDNF mRNA levels only displayed a minor change: an increase in CA1 at 
      1 hr after training. However, in a previous study we observed dramatically 
      decreased hippocampal BDNF mRNA levels in dentate gyrus and CA1 at 3 hr after 
      injection of corticosterone. In order to analyze this discrepancy, we 
      subsequently investigated if hippocampal BDNF mRNA expression is affected by 
      corticosterone at 3 hr after water maze training. Therefore, we incorporated ADX 
      animals and ADX animals which were injected with corticosterone in our study. ADX 
      animals which were subjected to water maze training displayed similar hippocampal 
      BDNF mRNA levels 3 hr after training compared to control ADX animals. 
      Furthermore, ADX animals which were injected with corticosterone showed decreased 
      BDNF mRNA levels in all hippocampal regions compared to control ADX animals. 
      Water maze training did not alter this effect. Thus, the increased corticosterone 
      levels during water maze training do not affect hippocampal BDNF mRNA expression, 
      although exogenous corticosterone is effective under these conditions. Hence, our 
      results suggest that in this situation BDNF is resistant to regulation by 
      endogenous corticosterone, which may be important for learning and memory 
      processes.
FAU - Schaaf, M J
AU  - Schaaf MJ
AD  - Leiden Amsterdam Center for Drug Research, Division of Medical Pharmacology, 
      Sylvius Laboratories, P.O. Box 9503, 2300 RA Leiden, The Netherlands.
FAU - Sibug, R M
AU  - Sibug RM
FAU - Duurland, R
AU  - Duurland R
FAU - Fluttert, M F
AU  - Fluttert MF
FAU - Oitzl, M S
AU  - Oitzl MS
FAU - De Kloet, E R
AU  - De Kloet ER
FAU - Vreugdenhil, E
AU  - Vreugdenhil E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Stress
JT  - Stress (Amsterdam, Netherlands)
JID - 9617529
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Mineralocorticoids)
RN  - 0 (RNA, Messenger)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenalectomy
MH  - Animals
MH  - Brain Chemistry/drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Conditioning, Psychological/physiology
MH  - Corticosterone/blood/*pharmacology
MH  - Dentate Gyrus/*physiology
MH  - Gene Expression/drug effects/physiology
MH  - In Situ Hybridization
MH  - Male
MH  - Maze Learning/*physiology
MH  - Mineralocorticoids/blood
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Physiological/*physiopathology
MH  - Swimming
EDAT- 2000/08/12 11:00
MHDA- 2000/09/19 11:01
CRDT- 2000/08/12 11:00
PHST- 2000/08/12 11:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 2000/08/12 11:00 [entrez]
AID - I405J991011 [pii]
AID - 10.3109/10253899909001121 [doi]
PST - ppublish
SO  - Stress. 1999 Dec;3(2):173-83. doi: 10.3109/10253899909001121.