PMID- 10938581
OWN - NLM
STAT- MEDLINE
DCOM- 20000915
LR  - 20220330
IS  - 1025-3890 (Print)
IS  - 1025-3890 (Linking)
VI  - 3
IP  - 3
DP  - 2000 May
TI  - Corticosterone effects on BDNF expression in the hippocampus. Implications for 
      memory formation.
PG  - 201-8
AB  - The adrenal steroid corticosterone has profound effect on the structure and 
      function of the hippocampus. Probably as a result of that, it modulates memory 
      formation. In this review, the question is addressed if the corticosterone 
      effects on memory processes are mediated by alterations in the expression of the 
      neurotrophin Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus. First, 
      studies are described investigating the effect of corticosterone on BDNF 
      expression in the rat hippocampus. It appears that corticosterone suppresses the 
      BDNF expression at the mRNA and protein level in a subfield-specific way. Second, 
      a model for the mechanism of action is proposed. In this model, activated 
      mineralocorticoid and glucocorticoid receptors repress transcriptional activity 
      of the BDNF promoter site-specifically via interaction with other transcription 
      factors. Third, the implications for learning and memory are discussed. Studies 
      show that during water maze training, corticosterone levels rise significantly, 
      but the BDNF expression is not suppressed in any hippocampal subfield. 
      Furthermore, high BDNF expression levels in specific subfields correlate with a 
      good memory performance. Therefore, we suggest that the resistance of the 
      hippocampal BDNF expression to suppression by corticosterone, as seen after water 
      maze training, may contribute to an optimal memory performance.
FAU - Schaaf, M J
AU  - Schaaf MJ
AD  - Leiden/Amsterdam Center for Drug Research, Division of Medical Pharmacology, 
      Sylvius Laboratories, P.O. Box 9503, 2300 RA Leiden, The Netherlands.
FAU - De Kloet, E R
AU  - De Kloet ER
FAU - Vreugdenhil, E
AU  - Vreugdenhil E
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Stress
JT  - Stress (Amsterdam, Netherlands)
JID - 9617529
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 0 (Receptors, Mineralocorticoid)
RN  - 0 (Serotonin Antagonists)
RN  - 5CLY6W2H1M (CRF receptor type 1)
RN  - SIV03811UC (Kainic Acid)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenalectomy
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/genetics
MH  - Corticosterone/*metabolism/pharmacology
MH  - Dentate Gyrus/drug effects/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Down-Regulation/genetics/physiology
MH  - Hippocampus/cytology/drug effects/*metabolism
MH  - Kainic Acid/pharmacology
MH  - Learning/drug effects/physiology
MH  - Memory/drug effects/*physiology
MH  - Models, Biological
MH  - Neurons/cytology/drug effects
MH  - Promoter Regions, Genetic/drug effects
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors
MH  - Receptors, Glucocorticoid/metabolism
MH  - Receptors, Mineralocorticoid/metabolism
MH  - Serotonin Antagonists/pharmacology
MH  - Stress, Physiological/metabolism
MH  - Transcription, Genetic/drug effects
RF  - 59
EDAT- 2000/08/12 11:00
MHDA- 2000/09/23 11:01
CRDT- 2000/08/12 11:00
PHST- 2000/08/12 11:00 [pubmed]
PHST- 2000/09/23 11:01 [medline]
PHST- 2000/08/12 11:00 [entrez]
AID - I405J991014 [pii]
AID - 10.3109/10253890009001124 [doi]
PST - ppublish
SO  - Stress. 2000 May;3(3):201-8. doi: 10.3109/10253890009001124.