PMID- 10940683
OWN - NLM
STAT- MEDLINE
DCOM- 20000921
LR  - 20220410
IS  - 0012-2823 (Print)
IS  - 0012-2823 (Linking)
VI  - 62 Suppl 1
DP  - 2000
TI  - Biological and molecular aspects of gastroenteropancreatic neuroendocrine tumors.
PG  - 19-26
AB  - Neuroendocrine tumors of the digestive tract are rare entities characterized by 
      significant phenotype differences and traditionally considered to originate from 
      cells of the diffuse endocrine system of the pancreas and gut. Two major 
      categories with significant phenotype and clinical behavior differences are 
      identified as well-differentiated and poorly differentiated tumors. Investigation 
      on the molecular basis of tumor development points to an important role for the 
      multiple endocrine neoplasia syndrome type-1 (MEN1) gene because of its frequent 
      abnormality observed both in well-differentiated and poorly differentiated 
      tumors. Other genes are possibly involved, though the available data need support 
      from studies on larger series of tumors.
CI  - Copyright 2000 S. Karger AG, Basel
FAU - Rindi, G
AU  - Rindi G
AD  - Department of Pathology, University of Brescia, Spedali Civili, Brescia, Italy. 
      rindi@master.cci.unibs.it
FAU - Villanacci, V
AU  - Villanacci V
FAU - Ubiali, A
AU  - Ubiali A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Animals
MH  - Biomarkers, Tumor/analysis
MH  - Cell Transformation, Neoplastic/genetics/pathology
MH  - Gastrointestinal Neoplasms/*genetics/*pathology
MH  - Genotype
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Neuroendocrine Tumors/*genetics/*pathology
MH  - Pancreatic Neoplasms/*genetics/*pathology
MH  - Phenotype
RF  - 65
EDAT- 2000/08/15 11:00
MHDA- 2000/09/23 11:01
CRDT- 2000/08/15 11:00
PHST- 2000/08/15 11:00 [pubmed]
PHST- 2000/09/23 11:01 [medline]
PHST- 2000/08/15 11:00 [entrez]
AID - 51851 [pii]
AID - 10.1159/000051851 [doi]
PST - ppublish
SO  - Digestion. 2000;62 Suppl 1:19-26. doi: 10.1159/000051851.