PMID- 10940736
OWN - NLM
STAT- MEDLINE
DCOM- 20000914
LR  - 20171101
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 72
IP  - 1
DP  - 2000 Jul
TI  - Immunolocalization of androgen receptors and aromatase enzyme in the adult musk 
      shrew brain.
PG  - 29-36
AB  - In the brain and other tissues, estrogens are produced by aromatization of 
      androgens. Biochemical data suggest that aromatase enzyme is regulated by the 
      androgen receptor (AR). Neurons that contain either AR or aromatase (AROM) enzyme 
      reside in many of the same brain regions. In this report, we examined the 
      codistribution of AR- and AROM-enzyme-immunoreactive (-ir) neurons in several 
      regions of the adult male and female musk shrew brain. Data were collected from 
      the intermediate nucleus of the lateral septum (LS), medial anterior (BNSTMA) and 
      medial posterointerior (BNSTMP) divisions of the bed nucleus of the stria 
      terminalis, medial preoptic area (mPOA), ventromedial nucleus of the hypothalamus 
      (VMN), medial (MeA), cortical and central nuclei of the amygdala. Males had 
      significantly more AR-ir neurons in the BNSTMP, mPOA, VMN and LS as compared to 
      females. With the exception of the BNSTMA and LS, males had more AROM-ir neurons 
      in each region than females. Furthermore, males had significantly more 
      double-labeled neurons than females in the BNSTMP, mPOA, VMN, LS and MeA. The 
      percentage of AROM-ir neurons that also contained AR immunoreactivity ranged from 
      13 to 82% depending on sex and region. The highest percentage of dual-labeled 
      neurons (79% in females and 82% in males) was found in the VMN. Taken together, 
      these data show that there is extensive cellular colocalization of AR and AROM 
      enzyme in specific regions of the musk shrew brain. We propose that in both 
      sexes, androgen receptors may act as transcription factors to regulate AROM 
      enzyme.
CI  - Copyright 2000 S. Karger AG, Basel
FAU - Veney, S L
AU  - Veney SL
AD  - Department of Biology, University of Virginia, Charlottesville, VA 22903, USA.
FAU - Rissman, E F
AU  - Rissman EF
LA  - eng
GR  - MH01349/MH/NIMH NIH HHS/United States
GR  - NS35429/NS/NINDS NIH HHS/United States
GR  - U54 HD96-008/HD/NICHD NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Antibodies)
RN  - 0 (Receptors, Androgen)
RN  - EC 1.14.14.1 (Aromatase)
SB  - IM
MH  - Age Factors
MH  - Amygdala/chemistry/enzymology
MH  - Animals
MH  - Antibodies
MH  - Aromatase/*analysis/immunology
MH  - Brain/*enzymology
MH  - Brain Chemistry/*physiology
MH  - Female
MH  - Immunohistochemistry
MH  - Male
MH  - Preoptic Area/chemistry/enzymology
MH  - Receptors, Androgen/*analysis/immunology
MH  - Septal Nuclei/chemistry/enzymology
MH  - Sex Factors
MH  - Shrews/*metabolism
MH  - Ventromedial Hypothalamic Nucleus/chemistry/enzymology
EDAT- 2000/08/15 11:00
MHDA- 2000/09/19 11:01
CRDT- 2000/08/15 11:00
PHST- 2000/08/15 11:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 2000/08/15 11:00 [entrez]
AID - 54568 [pii]
AID - 10.1159/000054568 [doi]
PST - ppublish
SO  - Neuroendocrinology. 2000 Jul;72(1):29-36. doi: 10.1159/000054568.