PMID- 10941806
OWN - NLM
STAT- MEDLINE
DCOM- 20001201
LR  - 20190910
IS  - 0770-3198 (Print)
IS  - 0770-3198 (Linking)
VI  - 19
IP  - 4
DP  - 2000
TI  - Changes of CD4/CD8 ratio and interleukin-16 in systemic lupus erythematosus.
PG  - 270-4
AB  - The authors investigated changes in the ratio of CD4+ to CD8+ T cells (CD4/CD8 
      ratio) and T-cell activation, indicated by human leukocyte antigen (HLA)-DR 
      expression, in patients with systemic lupus erythematosus (SLE) following 
      treatment. An increase was observed in the CD4/CD8 ratio as well as a decrease in 
      the expression of HLA-DR on T cells with the improvement of clinical 
      manifestations on treatment with steroids or cyclosporine (CSA). In addition, 
      steroid treatment suppressed whereas CSA treatment exerted no perceptible 
      influence on the serum interleukin (IL)-16 level, concurrent with changes in 
      T-cell phenotypes. This indicated that the mechanism of the change in the CD4/CD8 
      ratio differed depending on the drug, and CD8+ T cells could play an important 
      role in reducing this ratio. The CD4/CD8 ratio and HLA-DR expression may be good 
      indicators of therapeutic efficacy in some SLE patients.
FAU - Matsushita, M
AU  - Matsushita M
AD  - Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka, 
      Japan.
FAU - Hayashi, T
AU  - Hayashi T
FAU - Ando, S
AU  - Ando S
FAU - Sekigawa, I
AU  - Sekigawa I
FAU - Iida, N
AU  - Iida N
FAU - Hashimoto, H
AU  - Hashimoto H
FAU - Hirose, S
AU  - Hirose S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Antirheumatic Agents)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Interleukin-16)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Adult
MH  - Antirheumatic Agents/therapeutic use
MH  - *CD4-CD8 Ratio
MH  - Cyclosporine/therapeutic use
MH  - Data Interpretation, Statistical
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Interleukin-16/*analysis
MH  - Lupus Erythematosus, Systemic/*drug therapy/*immunology
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - T-Lymphocytes/immunology
EDAT- 2000/08/15 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/15 11:00
PHST- 2000/08/15 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/15 11:00 [entrez]
AID - 10.1007/pl00011171 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2000;19(4):270-4. doi: 10.1007/pl00011171.