PMID- 10941824
OWN - NLM
STAT- MEDLINE
DCOM- 20001228
LR  - 20190921
IS  - 0271-9142 (Print)
IS  - 0271-9142 (Linking)
VI  - 20
IP  - 3
DP  - 2000 May
TI  - Active immunization of humans with dendritic cells.
PG  - 167-74
AB  - Dendritic cells (DCs) are potent antigen-presenting cells specialized to initiate 
      T-cell immunity. The development of methods to generate large numbers of DCs has 
      facilitated their application for immunotherapy. Recent studies have demonstrated 
      the safety and immunogenicity of DCs in humans and have begun to outline the 
      durability, kinetics, and nature of the elicited T-cell responses. However, 
      DC-based immunotherapy remains a challenge and several parameters need to be 
      examined to optimize immune responses, in order to maximize clinical efficacy 
      against cancer and infectious diseases.
FAU - Dhodapkar, M V
AU  - Dhodapkar MV
AD  - Laboratory of Cellular Physiology and Immunology, Rockefeller University, New 
      York, New York 10021, USA.
FAU - Bhardwaj, N
AU  - Bhardwaj N
LA  - eng
GR  - AI 39516/AI/NIAID NIH HHS/United States
GR  - AI 44628/AI/NIAID NIH HHS/United States
GR  - CA 81138/CA/NCI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (Antigens)
SB  - IM
MH  - Antigens/administration & dosage
MH  - Cell Differentiation
MH  - Cell Movement/immunology
MH  - Cell Survival
MH  - Communicable Diseases/therapy
MH  - Dendritic Cells/classification/cytology/*immunology
MH  - Humans
MH  - Immunotherapy
MH  - Neoplasms/therapy
MH  - *Vaccination
RF  - 65
EDAT- 2000/08/15 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/15 11:00
PHST- 2000/08/15 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/15 11:00 [entrez]
AID - 10.1023/a:1006681312249 [doi]
PST - ppublish
SO  - J Clin Immunol. 2000 May;20(3):167-74. doi: 10.1023/a:1006681312249.