PMID- 10941829
OWN - NLM
STAT- MEDLINE
DCOM- 20001228
LR  - 20190921
IS  - 0271-9142 (Print)
IS  - 0271-9142 (Linking)
VI  - 20
IP  - 3
DP  - 2000 May
TI  - Elevation of IL-18 in human sepsis.
PG  - 212-5
AB  - Interleukin-18 (IL-18) is a recently identified immunoregulatory cytokine that 
      shares biochemical features with IL-1beta and acts in part by inducing 
      interferon-gamma (IFN-gamma). Endotoxic bacterial lipopolysaccharide (LPS) (1 or 
      2 ng/kg) was insufficient to increase plasma IL-18 in five healthy adults 
      measured 3, 12, and 24 hr following challenge. In contrast, in the first 96 hr of 
      admission to the surgical intensive care unit, mean maximal serum IL-18 was 
      elevated (1,122 +/- 259 pg/ml) in nine septic patients compared to six healthy 
      adults (191 +/- 42 pg/ml), P < 0.01). Serum IL-18 concentrations in septic 
      patients did not correlate with other measured inflammatory mediators: tumor 
      necrosis factor, IL-6, IL-10, or secretory leukocyte protease inhibitor. 
      Therefore, IL-18 circulates in healthy adults and is a component of the human 
      systemic inflammatory response. Further, stimuli other than LPS may induce IL-18 
      production in vivo in human sepsis.
FAU - Grobmyer, S R
AU  - Grobmyer SR
AD  - Department of Surgery, Weill Medical College of Cornell University, New York, New 
      York 10021, USA.
FAU - Lin, E
AU  - Lin E
FAU - Lowry, S F
AU  - Lowry SF
FAU - Rivadeneira, D E
AU  - Rivadeneira DE
FAU - Potter, S
AU  - Potter S
FAU - Barie, P S
AU  - Barie PS
FAU - Nathan, C F
AU  - Nathan CF
LA  - eng
GR  - GM08466/GM/NIGMS NIH HHS/United States
GR  - GM34695/GM/NIGMS NIH HHS/United States
GR  - GM53921/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-18)
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Interleukin-18/*blood
MH  - Lipopolysaccharides/toxicity
MH  - Male
MH  - Middle Aged
MH  - Sepsis/*immunology
EDAT- 2000/08/15 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/15 11:00
PHST- 2000/08/15 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/15 11:00 [entrez]
AID - 10.1023/a:1006641630904 [doi]
PST - ppublish
SO  - J Clin Immunol. 2000 May;20(3):212-5. doi: 10.1023/a:1006641630904.