PMID- 10942408
OWN - NLM
STAT- MEDLINE
DCOM- 20000907
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 96
IP  - 4
DP  - 2000 Aug 15
TI  - Blood group A and B antigens are strongly expressed on platelets of some 
      individuals.
PG  - 1574-81
AB  - It is widely thought that expression of ABH antigens on platelets is insufficient 
      to materially affect the survival of ABH-incompatible platelets in transfusion 
      recipients, but anecdotal reports of poor survival of A and B mismatched 
      platelets suggest that this is not always the case. The A and B antigen 
      expression on platelets of 100 group A(1) and group B blood donors was measured, 
      and 7% and 4%, respectively, had platelets whose A and B antigen levels 
      consistently exceeded the mean plus 2 SD. On the basis of flow cytometric and 
      statistical analysis, donors whose platelets contained higher than normal levels 
      of A antigen were subdivided into 2 groups, designated Type I and Type II ("high 
      expressers"). Serum A(1)- and B-glycosyltransferase levels of A and B high 
      expressers were significantly higher than those of group A(1) and B individuals 
      with normal expression. H antigen levels were low on the red cells of high 
      expressers, indicating that the anomaly affects other cell lineages. 
      Immunochemical studies demonstrated high levels of A antigen on various 
      glycoproteins (GPs) from high-expresser platelets, especially GPIIb and PECAM 
      (CD31). The A(1) Type II high-expresser phenotype was inherited as an autosomal 
      dominant trait in one family. The sequences of exons 5, 6, and 7 of the 
      A(1)-transferase gene of one Type II A(1) high expresser and exon 7 from 3 other 
      genes were identical to the reported normal sequences. Further studies are needed 
      to define the molecular basis for the high-expresser trait and to characterize 
      its clinical implications. (Blood. 2000;96:1574-1581)
FAU - Curtis, B R
AU  - Curtis BR
AD  - Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, 
      WI 53233, USA. brcurtis@bcsew.edu
FAU - Edwards, J T
AU  - Edwards JT
FAU - Hessner, M J
AU  - Hessner MJ
FAU - Klein, J P
AU  - Klein JP
FAU - Aster, R H
AU  - Aster RH
LA  - eng
GR  - R01 HL013629/HL/NHLBI NIH HHS/United States
GR  - HL-13629/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (ABO Blood-Group System)
SB  - IM
MH  - ABO Blood-Group System/biosynthesis/genetics/*immunology
MH  - Blood Platelets/*immunology
MH  - Female
MH  - Gene Expression Regulation/immunology
MH  - Humans
MH  - Male
MH  - Pedigree
EDAT- 2000/08/15 11:00
MHDA- 2000/09/09 11:01
CRDT- 2000/08/15 11:00
PHST- 2000/08/15 11:00 [pubmed]
PHST- 2000/09/09 11:01 [medline]
PHST- 2000/08/15 11:00 [entrez]
AID - S0006-4971(20)71980-4 [pii]
PST - ppublish
SO  - Blood. 2000 Aug 15;96(4):1574-81.