PMID- 10942806
OWN - NLM
STAT- MEDLINE
DCOM- 20000908
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 120
IP  - 2
DP  - 2000 Jul 15
TI  - Association of t(9;11)-MLL AF9 and trisomy 8 in an AML-M5 preceded by 
      pancytopenia.
PG  - 144-7
AB  - The implication of MLL gene rearrangements in the prognosis of acute myeloblastic 
      leukemia is an issue of considerable current interest. We report a case of a 
      young man who initially presented with a pancytopenia and went on to develop a 
      highly-aggressive acute myeloblastic leukemia. At this time, the karyotypic study 
      revealed trisomy 8, a t(9;11) was demonstrated by fluorescence in situ 
      hybridization (FISH) and the MLL/AF4 rearrangement by reverse 
      transcriptase-polymerase chain reaction (RT-PCR).
FAU - Anguita, E
AU  - Anguita E
AD  - Hematology Department, Hospital Clinico San Carlos, Madrid, Spain.
FAU - Barrio, C G
AU  - Barrio CG
FAU - Gonzalez, F A
AU  - Gonzalez FA
FAU - Ferro, M T
AU  - Ferro MT
FAU - del Potro, E
AU  - del Potro E
FAU - Ropero, P
AU  - Ropero P
FAU - Villegas, A
AU  - Villegas A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA, Neoplasm)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KMT2A protein, human)
RN  - 0 (MLLT3 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Transcription Factors)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Adult
MH  - Blotting, Southern
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Chromosomes, Human, Pair 9/*genetics
MH  - Cytogenetic Analysis
MH  - DNA, Neoplasm/genetics
MH  - DNA-Binding Proteins/genetics
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Monocytic, Acute/*genetics/pathology
MH  - Male
MH  - Myeloid-Lymphoid Leukemia Protein
MH  - Nuclear Proteins/genetics
MH  - Oncogene Proteins, Fusion/genetics
MH  - Pancytopenia/genetics/*pathology
MH  - *Proto-Oncogenes
MH  - *Transcription Factors
MH  - Translocation, Genetic
MH  - *Trisomy
EDAT- 2000/08/16 11:00
MHDA- 2000/09/19 11:01
CRDT- 2000/08/16 11:00
PHST- 2000/08/16 11:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 2000/08/16 11:00 [entrez]
AID - S0165-4608(99)00260-5 [pii]
AID - 10.1016/s0165-4608(99)00260-5 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Jul 15;120(2):144-7. doi: 
      10.1016/s0165-4608(99)00260-5.