PMID- 10943698
OWN - NLM
STAT- MEDLINE
DCOM- 20010104
LR  - 20220310
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 11
IP  - 11
DP  - 2000 Aug 3
TI  - The effects of intra-vestibular nucleus administration of brain-derived 
      neurotrophic factor (BDNF) on recovery from peripheral vestibular damage in 
      guinea pig.
PG  - 2429-32
AB  - Brain-derived neurotrophic factor (BDNF), at doses of 0.04, 0.4 or 4.0 
      microg/day, was delivered by cannula and s.c osmotic minipump into the 
      ipsilateral vestibular nucleus complex from 0 to 50 h following unilateral 
      labyrinthectomy (UL) in guinea pigs. Compared to the vehicle control group, the 
      frequency of spontaneous nystagmus was significantly reduced (p < 0.02) and the 
      rate of yaw head tilt compensation increased (p < 0.02). However, roll head tilt 
      was not signifcantly affected. There were also no significant effects of BDNF 
      administration into the IVth ventricle (4.0 microg/day) on any UL symptom. These 
      results further support the hypothesis that neurotrophins such as BDNF may 
      enhance the vestibular compensation process.
FAU - Maingay, M G
AU  - Maingay MG
AD  - Department of Pharmacology, School of Medical Sciences, University of Otago 
      Medical School, Dunedin, New Zealand.
FAU - Sansom, A J
AU  - Sansom AJ
FAU - Kerr, D R
AU  - Kerr DR
FAU - Smith, P F
AU  - Smith PF
FAU - Darlington, C L
AU  - Darlington CL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism/*pharmacology
MH  - Denervation/adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Guinea Pigs
MH  - Neuronal Plasticity/*drug effects/physiology
MH  - Nystagmus, Pathologic/drug therapy/etiology/physiopathology
MH  - Posture/physiology
MH  - Recovery of Function/*drug effects/physiology
MH  - Vestibular Diseases/*drug therapy/pathology/physiopathology
MH  - Vestibular Nuclei/cytology/*drug effects/metabolism
MH  - Vestibule, Labyrinth/pathology/*physiopathology/surgery
EDAT- 2000/08/16 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/16 11:00
PHST- 2000/08/16 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/16 11:00 [entrez]
AID - 10.1097/00001756-200008030-00018 [doi]
PST - ppublish
SO  - Neuroreport. 2000 Aug 3;11(11):2429-32. doi: 10.1097/00001756-200008030-00018.