PMID- 10946251
OWN - NLM
STAT- MEDLINE
DCOM- 20001030
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 469
IP  - 1
DP  - 2000 Aug 21
TI  - Equal induction and persistence of chromosome aberrations involving chromosomes 
      1, 4 and 10 in thyroid cancer patients treated with radioactive iodine.
PG  - 147-58
AB  - A number of in vitro studies have questioned the assumption of random 
      distribution of breaks in radiation-induced chromosome aberrations. The 
      therapeutic application of radioactive 131I in thyroid cancer patients offers a 
      good opportunity to study the induction and persistence of cytogenetic damage 
      involving different chromosomes in vivo. Using whole-chromosome painting probes 
      and triple colour painting by fluorescence in situ hybridization (FISH), we have 
      analysed the frequency of chromosomal aberrations (CAs) involving chromosomes 1, 
      4 and 10 in peripheral blood lymphocytes of 10 thyroid cancer patients sampled 
      before and 1 week, 1 year and 3.5 years after therapeutic application of 
      radioactive iodine in a self-controlled, longitudinal study. A highly significant 
      3.4-fold increase in the frequency of chromosome breaks was observed 1 week after 
      treatment with a similar representation of all chromosomes analysed. Although a 
      significant decrease in dicentrics was observed during the first year after 
      treatment, the frequency of chromosome aberrations remained over control levels 
      until the last sampling time, 41-47 months post-treatment. The same behaviour, in 
      terms of induction and persistence, was observed for all three chromosomes, 
      confirming our previous results in vitro and rejecting the reported suggestion 
      that chromosome 10 is radiosensitive in vivo. Our finding that the dynamics of 
      radiation-induced CA in vivo is independent on the chromosome of choice suggests 
      that this variable is not important in retrospective studies.
FAU - Puerto, S
AU  - Puerto S
AD  - Grup de Mutagenesi, Unitat de Genet., Departament de Genetica i de Microbiologia, 
      Edifici Cn, Universitat Autonoma de Barcelona, 08193, Bellaterra (Cerdanyola des 
      Valles), Spain.
FAU - Marcos, R
AU  - Marcos R
FAU - Ramirez, M J
AU  - Ramirez MJ
FAU - Galofre, P
AU  - Galofre P
FAU - Creus, A
AU  - Creus A
FAU - Surralles, J
AU  - Surralles J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Iodine Radioisotopes)
SB  - IM
MH  - Adult
MH  - Child
MH  - *Chromosome Aberrations
MH  - Chromosome Mapping
MH  - Chromosome Painting/methods
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 10
MH  - *Chromosomes, Human, Pair 4
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Iodine Radioisotopes/*therapeutic use
MH  - Lymphocytes/*radiation effects
MH  - Middle Aged
MH  - Radiotherapy Dosage
MH  - Thyroid Neoplasms/blood/*radiotherapy
MH  - Time Factors
EDAT- 2000/08/18 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/18 11:00
PHST- 2000/08/18 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/18 11:00 [entrez]
AID - S1383571800000644 [pii]
AID - 10.1016/s1383-5718(00)00064-4 [doi]
PST - ppublish
SO  - Mutat Res. 2000 Aug 21;469(1):147-58. doi: 10.1016/s1383-5718(00)00064-4.