PMID- 10948671
OWN - NLM
STAT- MEDLINE
DCOM- 20000908
LR  - 20161020
IS  - 1122-0643 (Print)
IS  - 1122-0643 (Linking)
VI  - 55
IP  - 3
DP  - 2000 Jun
TI  - Dendritic cells: pulmonary immune regulation and asthma.
PG  - 225-30
AB  - Dendritic cells (DCs) may play a pivotal role in the initiation and establishment 
      of chronic T-helper cell (Th)-2 mediated lung inflammation as seen in asthma. 
      Current in vitro data indicate that the haemopoietic lineage of the DC or the 
      local environment in which a DC matures, or both acting together, can instruct 
      the DC to become a Th1- or Th2-inducing antigen-presenting cell. Once 
      allergen-specific Th2 memory cells are drawn into the lung, repeated allergen 
      presentation by lung DCs may drive the persistent stimulation of 
      allergen-specific memory Th2 cells and precipitate a state of chronic 
      inflammation that contributes to the remodelling and hyperreactive airways that 
      characterize asthma. In addition, the persistent stimulation of effector Th2 
      cells and the subsequent Th2 cytokine secretion can create a Th2 cytokine milieu 
      in the lung that may influence the differentiation of antigen-specific Th0 in the 
      lung and naive Th in the lung-associated lymph nodes to develop into Th2 effector 
      cells. Immunoglobulin E receptors on antigen-presenting cells may facilitate 
      chronic T-helper cell-2 inflammation directly by focusing allergen to dendritic 
      cells for uptake and indirectly by stimulating alveolar macrophages to secrete 
      mediators that lead to the maturation of dendritic cells with a low capacity to 
      secrete interleukin-12.
FAU - Masten, B J
AU  - Masten BJ
AD  - Dept of Pathology, University of New Mexico, Albuquerque, USA.
FAU - Lipscomb, M F
AU  - Lipscomb MF
LA  - eng
GR  - F32 HL09546/HL/NHLBI NIH HHS/United States
GR  - P50 HL56384/HL/NHLBI NIH HHS/United States
GR  - R01 AI 21951/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Italy
TA  - Monaldi Arch Chest Dis
JT  - Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
JID - 9307314
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Asthma/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Inflammation Mediators/immunology
MH  - Pulmonary Alveoli/cytology
MH  - T-Lymphocytes, Helper-Inducer/*immunology
RF  - 51
EDAT- 2000/08/19 11:00
MHDA- 2000/09/19 11:01
CRDT- 2000/08/19 11:00
PHST- 2000/08/19 11:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 2000/08/19 11:00 [entrez]
PST - ppublish
SO  - Monaldi Arch Chest Dis. 2000 Jun;55(3):225-30.