PMID- 10950057
OWN - NLM
STAT- MEDLINE
DCOM- 20000830
LR  - 20151119
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 95
IP  - 8
DP  - 2000 Aug
TI  - Human leukocyte antigen DR markers as predictors of progression to liver 
      transplantation in patients with chronic hepatitis C.
PG  - 2056-60
AB  - OBJECTIVE: Because many patients with chronic viral hepatitis do not progress to 
      end-stage liver disease, it is possible that host factors such as human leukocyte 
      antigen (HLA) differences are important. Our aims were to determine HLA 
      marker-specific rates of progression to liver transplantation among patients with 
      chronic hepatitis C; and to determine if polymerase chain reaction (PCR)-based 
      HLA DRB1 typing can be performed on stored serum samples. METHODS: Forty-two 
      hepatitis C virus RNA-positive liver transplant patients and 87 untransplanted 
      patients were included in a Cox proportional hazards model to test whether the 
      occurrence of certain HLA DRB1 markers were associated with progression to liver 
      transplantation. HLA DRB1 typing was performed on stored serum samples using a 
      PCR method. RESULTS: There were no differences among the HLA DRB1 markers with 
      regard to the HLA marker-specific rate of progression to transplantation among 
      patients with chronic hepatitis C. CONCLUSIONS: HLA DRB1 markers do not appear to 
      be associated with progression of disease in chronic viral hepatitis C. It is 
      possible to perform PCR-based HLA DRB1 typing on stored frozen serum samples.
FAU - Brandhagen, D J
AU  - Brandhagen DJ
AD  - Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, 
      Minnesota, USA.
FAU - Gross, J B Jr
AU  - Gross JB Jr
FAU - Poterucha, J J
AU  - Poterucha JJ
FAU - Germer, J J
AU  - Germer JJ
FAU - Czaja, A J
AU  - Czaja AJ
FAU - Smith, C I
AU  - Smith CI
FAU - Ribeiro, A C
AU  - Ribeiro AC
FAU - Guerrero, R B
AU  - Guerrero RB
FAU - Therneau, T M
AU  - Therneau TM
FAU - Schiff, E
AU  - Schiff E
FAU - Gordon, F D
AU  - Gordon FD
FAU - Wiesner, R H
AU  - Wiesner RH
FAU - Persing, D H
AU  - Persing DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Adult
MH  - Biomarkers/analysis
MH  - Disease Progression
MH  - Female
MH  - HLA-DR Antigens/*analysis
MH  - HLA-DRB1 Chains
MH  - Hepacivirus/genetics
MH  - Hepatitis C, Chronic/genetics/*immunology/*surgery/virology
MH  - Humans
MH  - *Liver Transplantation
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction/methods
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - RNA, Viral/analysis
EDAT- 2000/08/19 11:00
MHDA- 2000/09/02 11:01
CRDT- 2000/08/19 11:00
PHST- 2000/08/19 11:00 [pubmed]
PHST- 2000/09/02 11:01 [medline]
PHST- 2000/08/19 11:00 [entrez]
AID - S0002-9270(00)00929-1 [pii]
AID - 10.1111/j.1572-0241.2000.02137.x [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2000 Aug;95(8):2056-60. doi: 
      10.1111/j.1572-0241.2000.02137.x.