PMID- 10950138
OWN - NLM
STAT- MEDLINE
DCOM- 20000919
LR  - 20061115
IS  - 1090-0233 (Print)
IS  - 1090-0233 (Linking)
VI  - 160
IP  - 1
DP  - 2000 Jul
TI  - Comparative genomic hybridization (CGH) in dogs--application to the study of a 
      canine glial tumour cell line.
PG  - 77-82
AB  - Recurrent chromosome aberrations are associated with many human cancers. Detailed 
      cytogenetic analysis of tumors has benefited enormously from the development of 
      molecular cytogenetic techniques based on fluorescence in situ hybridization 
      (FISH). Comparative genomic hybridization (CGH) is a recently developed FISH 
      technique that allows a rapid and comprehensive identification of imbalanced 
      genomic material in tumour DNA. Comparative genomic hybridisation has been used 
      widely in human medicine to evaluate losses and gains of tumour DNA isolated from 
      a variety of sources, including fresh samples, cell-culture material and archival 
      specimens, and has been instrumental in identifying sites in the human genome 
      which contain genies involved in tumour development and progression. This report 
      describes the first application of CGH in the dog, illustrated by the analysis of 
      DNA isolated from a canine glial tumour cell line.
FAU - Dunn, K A
AU  - Dunn KA
AD  - Pathology Section, Animal Health Trust, Newmarket, Suffolk, UK. 
      karen.dunn@aht.org.uk
FAU - Thomas, R
AU  - Thomas R
FAU - Binns, M M
AU  - Binns MM
FAU - Breen, M
AU  - Breen M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Vet J
JT  - Veterinary journal (London, England : 1997)
JID - 9706281
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Animals
MH  - Brain Neoplasms/genetics/*veterinary
MH  - DNA, Neoplasm/genetics
MH  - Dog Diseases/*genetics
MH  - Dogs
MH  - Glioma/genetics/*veterinary
MH  - In Situ Hybridization, Fluorescence
MH  - Tumor Cells, Cultured
EDAT- 2000/08/19 11:00
MHDA- 2000/09/23 11:01
CRDT- 2000/08/19 11:00
PHST- 2000/08/19 11:00 [pubmed]
PHST- 2000/09/23 11:01 [medline]
PHST- 2000/08/19 11:00 [entrez]
AID - S1090-0233(00)90495-7 [pii]
AID - 10.1053/tvjl.2000.0495 [doi]
PST - ppublish
SO  - Vet J. 2000 Jul;160(1):77-82. doi: 10.1053/tvjl.2000.0495.