PMID- 10951978
OWN - NLM
STAT- MEDLINE
DCOM- 20001221
LR  - 20190915
IS  - 0002-9645 (Print)
IS  - 0002-9645 (Linking)
VI  - 61
IP  - 8
DP  - 2000 Aug
TI  - Effects of intranasal inoculation of porcine reproductive and respiratory 
      syndrome virus, Bordetella bronchiseptica, or a combination of both organisms in 
      pigs.
PG  - 892-9
AB  - OBJECTIVE: To examine effects of co-infection with porcine reproductive and 
      respiratory syndrome virus (PRRSV) and Bordetella bronchiseptica in pigs. 
      ANIMALS: Forty 3-week-old pigs. Procedure-30 pigs (10 pigs/group) were inoculated 
      with PRRSV, B bronchiseptica, or both. Ten noninoculated pigs were control 
      animals. RESULTS: Clinical signs, febrile response, and decreased weight gain 
      were most severe in the group inoculated with both organisms. The PRRSV was 
      isolated from all pigs in both groups inoculated with virus. All pigs in both 
      groups that received PRRSV had gross and microscopic lesions consistent with 
      interstitial pneumonia. Bordetella bronchiseptica was cultured from all pigs in 
      both groups inoculated with that bacterium. Colonization of anatomic sites by B 
      bronchiseptica was comparable between both groups. Pigs in the group that 
      received only B bronchiseptica lacked gross or microscopic lung lesions, and B 
      bronchiseptica was not isolated from lung tissue. In the group inoculated with B 
      bronchiseptica and PRRSV, 3 of 5 pigs 10 days after inoculation and 5 of 5 pigs 
      21 days after inoculation had gross and microscopic lesions consistent with 
      bacterial bronchopneumonia, and B bronchiseptica was isolated from the lungs of 7 
      of those 10 pigs. CONCLUSIONS AND CLINICAL RELEVANCE: Clinical disease was 
      exacerbated in co-infected pigs, including an increased febrile response, 
      decreased weight gain, and B bronchiseptica-induced pneumonia. Bordetella 
      bronchiseptica and PRRSV may circulate in a herd and cause subclinical 
      infections. Therefore, co-infection with these organisms may cause clinical 
      respiratory tract disease and leave pigs more susceptible to subsequent infection 
      with opportunistic bacteria.
FAU - Brockmeier, S L
AU  - Brockmeier SL
AD  - Respiratory Diseases of Livestock Research Unit, National Animal Disease Center, 
      USDA, Ames, IA 50010, USA.
FAU - Palmer, M V
AU  - Palmer MV
FAU - Bolin, S R
AU  - Bolin SR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Vet Res
JT  - American journal of veterinary research
JID - 0375011
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Agglutination Tests/veterinary
MH  - Animals
MH  - Antibodies, Bacterial/blood
MH  - Antibodies, Viral/blood
MH  - Body Temperature
MH  - Body Weight
MH  - Bordetella Infections/blood/complications/pathology/*veterinary
MH  - Bordetella bronchiseptica/*pathogenicity
MH  - Bronchoalveolar Lavage/veterinary
MH  - Bronchoalveolar Lavage Fluid/virology
MH  - Colony Count, Microbial
MH  - Cough/veterinary
MH  - Enzyme-Linked Immunosorbent Assay/veterinary
MH  - Lung/microbiology/pathology/virology
MH  - Porcine Reproductive and Respiratory Syndrome/blood/*pathology/virology
MH  - Porcine respiratory and reproductive syndrome virus/*pathogenicity
MH  - Random Allocation
MH  - Swine
MH  - Trachea/microbiology/pathology/virology
MH  - Turbinates/microbiology/pathology/virology
EDAT- 2000/08/22 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/22 11:00
PHST- 2000/08/22 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/22 11:00 [entrez]
AID - 10.2460/ajvr.2000.61.892 [doi]
PST - ppublish
SO  - Am J Vet Res. 2000 Aug;61(8):892-9. doi: 10.2460/ajvr.2000.61.892.