PMID- 10952030
OWN - NLM
STAT- MEDLINE
DCOM- 20001228
LR  - 20141120
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 22
IP  - 2
DP  - 2000 May
TI  - Inhibitory effect of mast cell-mediated immediate-type allergic reactions by 
      sulfapyridine.
PG  - 253-66
AB  - We examined the effect of sulfapyridine on mast cell-mediated immediate-type 
      allergic reactions. Sulfapyridine (1 and 10 microg/kg) significantly inhibited 
      systemic allergic reaction induced by compound 48/80 in rats. Sulfapyridine (1 
      and 10 microg/kg) also inhibited significantly local mast cell-mediated 
      immediate-type allergic reactions activated by anti-dinitrophenyl (DNP) IgE. 
      Moreover, sulfapyridine inhibited histamine release dose-dependently in the rat 
      peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. When 
      sulfapyridine was added, the level of cAMP in RPMC, transiently and significantly 
      increased about 4-fold compared with that of basal cells. These results indicate 
      that sulfapyridine inhibits mast cell-mediated immediate-type allergic reactions 
      in vivo and in vitro.
FAU - Kim, H M
AU  - Kim HM
AD  - College of Pharmacy, Professional Graduate School of Oriental Medicine, Center of 
      Oriental Medicinal Science, Wonkwang University, Iksan, Chonbuk, South Korea. 
      hmkim@wonnms.wonkwang.ac.kr
FAU - An, N H
AU  - An NH
FAU - Yi, B H
AU  - Yi BH
FAU - Chae, H J
AU  - Chae HJ
FAU - Kim, H R
AU  - Kim HR
FAU - Moon, S J
AU  - Moon SJ
FAU - Kim, J J
AU  - Kim JJ
FAU - Park, S T
AU  - Park ST
FAU - Baek, S H
AU  - Baek SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Dinitrophenols)
RN  - 0 (Serum Albumin)
RN  - 0 (dinitrophenyl-human serum albumin conjugate)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - E0399OZS9N (Cyclic AMP)
RN  - Y5V2N1KE8U (Sulfapyridine)
SB  - IM
MH  - Animals
MH  - Cyclic AMP/metabolism
MH  - Dinitrophenols/immunology
MH  - Histamine Release/drug effects
MH  - Hypersensitivity, Immediate/*prevention & control
MH  - Immunity, Cellular/drug effects
MH  - In Vitro Techniques
MH  - Mast Cells/*drug effects/*immunology/metabolism
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Peritoneal Cavity/cytology
MH  - Rats
MH  - Rats, Wistar
MH  - Serum Albumin/immunology
MH  - Sulfapyridine/*pharmacology
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 2000/08/22 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/22 11:00
PHST- 2000/08/22 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/22 11:00 [entrez]
AID - 10.3109/08923970009016419 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2000 May;22(2):253-66. doi: 
      10.3109/08923970009016419.