PMID- 10952031
OWN - NLM
STAT- MEDLINE
DCOM- 20001228
LR  - 20181130
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 22
IP  - 2
DP  - 2000 May
TI  - Suppression of immunoglobulin E-mediated anaphylactic reaction by Alpinia 
      oxyphylla in rats.
PG  - 267-77
AB  - We investigated the effect of Alpinia oxyphylla water extract (AOWE) on 
      immunoglobulin E (IgE)-mediated anaphylaxis activated by anti-dinitrophenyl (DNP) 
      IgE antibody. AOWE dose-dependently suppressed passive cutaneous anaphylaxis 
      (PCA) when intraperitoneally or orally administered. On the other hand, it showed 
      weak suppressive activity when administered intravenously. AOWE dose-dependently 
      suppressed anaphylactic histamine release from rat peritoneal mast cells (RPMC) 
      activated by anti-DNP IgE antibody. However, AOWE had a significant augmenting 
      effect on anti-DNP IgE antibody-induced tumor necrosis factor-alpha secretion 
      from RPMC. These results indicated that AOWE may possess strong antianaphylactic 
      action and also suggest that differential activity following administration 
      routes may be caused by difference of bioavailability.
FAU - Kim, S H
AU  - Kim SH
AD  - College of Pharmacy, Woosuk University, Chonju, Chonbuk, South Korea.
FAU - Choi, Y K
AU  - Choi YK
FAU - Jeong, H J
AU  - Jeong HJ
FAU - Kang, H U
AU  - Kang HU
FAU - Moon, G
AU  - Moon G
FAU - Shin, T Y
AU  - Shin TY
FAU - Kim, H M
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Histamine Release/drug effects
MH  - Immunoglobulin E/*metabolism
MH  - In Vitro Techniques
MH  - Male
MH  - Mast Cells/drug effects/immunology
MH  - Passive Cutaneous Anaphylaxis/*drug effects/immunology
MH  - Plant Extracts/administration & dosage/pharmacology
MH  - *Plants, Medicinal
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - *Zingiberales
EDAT- 2000/08/22 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/22 11:00
PHST- 2000/08/22 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/22 11:00 [entrez]
AID - 10.3109/08923970009016420 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2000 May;22(2):267-77. doi: 
      10.3109/08923970009016420.