PMID- 10955565
OWN - NLM
STAT- MEDLINE
DCOM- 20001207
LR  - 20191104
IS  - 0179-0358 (Print)
IS  - 0179-0358 (Linking)
VI  - 16
IP  - 5-6
DP  - 2000
TI  - The relation between human leukocyte antigen (HLA) distribution and intestinal 
      obstruction and adhesions in childhood: preliminary report.
PG  - 374-6
AB  - To investigate the association between the human leukocyte antigen (HLA) system 
      and adhesions causing intestinal obstruction in childhood in order to determine 
      whether HLA profiles can be used to identify and screen individuals at risk for 
      intestinal adhesions, clinical and laboratory evaluations were done in a total of 
      42 (F:M = 27:15) patients. The mean age was 6.11 +/- 3.2 years (0.6-13 years). 
      The patients were tested for HLA phenotype in two groups; the HLA phenotype 
      distribution and relative risk (RR) for adhesions were determined. The study 
      patients were children operated upon due to acute abdominal emergencies. Group 1 
      included patients who needed readmission after the surgery due to intestinal 
      obstruction (n = 19), group 2 patients had no readmission for any reason 
      following surgery (n = 23). Of the 19 patients in group 1, 9 were treated only 
      medically and 10 needed surgical intervention. Among the patients in whom medical 
      treatment was initiated (n = 14), 5 needed surgery during follow-up. There was an 
      increased RR for certain HLA subtypes (A24 [9], HLA11, DR11 [5], B22) in patients 
      presenting with intestinal obstruction due to adhesions. Among these, A24 (9) and 
      DR11 (5) were statistically significant (P < 0.05) compared with the control 
      group. Several possible mechanisms could link the HLA system with disease, 
      especially those in which the immune response is suspected to be involved, but 
      the questions of how the inflammatory response is initiated and the role of 
      proinflammatory cytokines remain unclear. Future research developments are likely 
      to focus on increased understanding of the molecular biology of the major 
      histocompatibility complex and its biological function in the immune response and 
      adhesion formation and intestinal obstruction. It is possible that HLA profiles 
      can be used to identify individuals at risk for intestinal adhesions in the 
      future.
FAU - Erdogan, E
AU  - Erdogan E
AD  - Department of Pediatric Surgery, Cerrahpasa Medical Faculty, University of 
      Istanbul, Turkey.
FAU - Celayir, S
AU  - Celayir S
FAU - Eroglu, E
AU  - Eroglu E
FAU - Yilmaz, E
AU  - Yilmaz E
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pediatr Surg Int
JT  - Pediatric surgery international
JID - 8609169
RN  - 0 (Cytokines)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A11 Antigen)
RN  - 0 (HLA-A24 Antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B22 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR11 antigen)
SB  - IM
MH  - Abdomen, Acute/*surgery
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/immunology
MH  - Genetic Testing
MH  - HLA-A Antigens/*genetics
MH  - HLA-A11 Antigen
MH  - HLA-A24 Antigen
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DR Serological Subtypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Inflammation
MH  - Intestinal Diseases/diagnostic imaging/*genetics/immunology/surgery
MH  - Intestinal Obstruction/diagnostic imaging/*genetics/immunology/surgery
MH  - Patient Readmission
MH  - Phenotype
MH  - Postoperative Complications/diagnostic imaging/*etiology/surgery
MH  - Radiography
MH  - Risk
MH  - Risk Factors
MH  - Tissue Adhesions/diagnostic imaging/*genetics/immunology/surgery
EDAT- 2000/08/24 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/24 11:00
PHST- 2000/08/24 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/24 11:00 [entrez]
AID - 10.1007/s003830000350 [doi]
PST - ppublish
SO  - Pediatr Surg Int. 2000;16(5-6):374-6. doi: 10.1007/s003830000350.