PMID- 10956365
OWN - NLM
STAT- MEDLINE
DCOM- 20001019
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 89
IP  - 3
DP  - 2000 Sep
TI  - Protein- and carbohydrate-induced augmentation of whole body creatine retention 
      in humans.
PG  - 1165-71
AB  - This study investigated the effect of creatine supplementation in conjunction 
      with protein and/or carbohydrate (CHO) ingestion on plasma creatine and serum 
      insulin concentrations and whole body creatine retention. Twelve men consumed 4 x 
      5 g of creatine on four occasions in combination with 1) 5 g of CHO, 2) 50 g of 
      protein and 47 g of CHO, 3) 96 g of CHO, or 4) 50 g of CHO. The increase in serum 
      insulin was no different when the protein-CHO and high-CHO treatments were 
      compared, but both were greater than the response recorded for the low-CHO 
      treatment (both P < 0.05). As a consequence, body creatine retention was 
      augmented by approximately 25% for protein-CHO and high-CHO treatments compared 
      with placebo treatment. The areas under creatine- and insulin-time curves were 
      related during the first oral challenge (r = -0.920, P < 0.05) but not after the 
      fourth (r = -0.342). It is concluded, first, that the ingestion of creatine in 
      conjunction with approximately 50 g of protein and CHO is as effective at 
      potentiating insulin release and creatine retention as ingesting creatine in 
      combination with almost 100 g of CHO. Second, the stimulatory effect of insulin 
      on creatine disposal was diminished within the initial 24 h of supplementation.
FAU - Steenge, G R
AU  - Steenge GR
AD  - School of Biomedical Sciences, University Medical School, Queen's Medical Centre, 
      Nottingham NG7 2UH, United Kingdom.
FAU - Simpson, E J
AU  - Simpson EJ
FAU - Greenhaff, P L
AU  - Greenhaff PL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
RN  - 0 (Insulin)
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Creatine/blood/*metabolism/urine
MH  - Dietary Carbohydrates/*pharmacology
MH  - Dietary Proteins/*pharmacology
MH  - Humans
MH  - Insulin/blood
MH  - Male
EDAT- 2000/08/24 11:00
MHDA- 2000/10/21 11:01
CRDT- 2000/08/24 11:00
PHST- 2000/08/24 11:00 [pubmed]
PHST- 2000/10/21 11:01 [medline]
PHST- 2000/08/24 11:00 [entrez]
AID - 10.1152/jappl.2000.89.3.1165 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2000 Sep;89(3):1165-71. doi: 10.1152/jappl.2000.89.3.1165.