PMID- 10958834
OWN - NLM
STAT- MEDLINE
DCOM- 20001003
LR  - 20180330
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 130
IP  - 9
DP  - 2000 Sep
TI  - Long-term consumption of a methionine-supplemented diet increases iron and lipid 
      peroxide levels in rat liver.
PG  - 2349-55
AB  - Methionine is a protective factor against various types of liver damage, but 
      excessive dietary methionine is hepatotoxic. Because the mechanisms of 
      L-methionine-related hepatotoxicity are poorly understood, the effect of 
      long-term excessive L-methionine intake on the metabolism of iron and 
      antioxidants was studied in rat liver to determine whether oxidative stress is 
      involved. Wistar male rats were fed either an L-methionine-supplemented (16.0 
      g/kg) diet or a control diet for 1, 3, 6 and 9 mo. The growth rate of 
      L-methionine-supplemented rats was significantly slower than that of controls. 
      Iron, ferritin and thiobarbituric acid-reactive substances (TBARS) levels in the 
      liver were greater in supplemented rats than in controls. Serum iron and 
      transferrin levels were significantly lower in L-methionine-treated rats compared 
      with controls. Serum ferritin did not differ between the two groups. Hepatic 
      glutathione peroxidase activity, catalase activity and total glutathione 
      concentrations were higher in rats fed the L-methionine-supplemented diet at 1 
      and 3 mo, but not at 6 and 9 mo. These results indicate that long-term 
      consumption of excess L-methionine by rats may affect primarily iron metabolism 
      rather than the antioxidant defense system and, consequently, induce an 
      accumulation of iron.
FAU - Mori, N
AU  - Mori N
AD  - College of Medical Science, Kumamoto University, 4-24-1 Kuhonji, Kumamoto 
      862-0976, Japan.
FAU - Hirayama, K
AU  - Hirayama K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Antioxidants)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 9007-73-2 (Ferritins)
RN  - AE28F7PNPL (Methionine)
RN  - E1UOL152H7 (Iron)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Body Weight/drug effects
MH  - Catalase/metabolism
MH  - Diet
MH  - Dose-Response Relationship, Drug
MH  - Ferritins/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Iron/blood/*metabolism
MH  - Lipid Peroxidation/*drug effects
MH  - Liver/*drug effects/enzymology/metabolism
MH  - Male
MH  - Methionine/administration & dosage/*pharmacology
MH  - Oxidative Stress
MH  - Rats
MH  - Rats, Wistar
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2000/08/26 11:00
MHDA- 2000/10/07 11:01
CRDT- 2000/08/26 11:00
PHST- 2000/08/26 11:00 [pubmed]
PHST- 2000/10/07 11:01 [medline]
PHST- 2000/08/26 11:00 [entrez]
AID - 10.1093/jn/130.9.2349 [doi]
PST - ppublish
SO  - J Nutr. 2000 Sep;130(9):2349-55. doi: 10.1093/jn/130.9.2349.