PMID- 10958896
OWN - NLM
STAT- MEDLINE
DCOM- 20001128
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 402
IP  - 3
DP  - 2000 Aug 25
TI  - Effect of TEI-9874, an inhibitor of immunoglobulin E production, on 
      allergen-induced asthmatic model in rats.
PG  - 287-95
AB  - As TEI-9874, 2-(4-(6-cyclohexyloxy-2-naphtyloxy)phenylacetamide)ben zoic acid 
      reduces allergen-specific immunoglobulin E (IgE) production by human peripheral 
      blood mononuclear cells in vitro, we evaluated its potency on an allergen-induced 
      asthmatic model in Brown-Norway rats. Inhaled ovalbumin induced the 
      immediate-phase asthmatic response, the late-phase asthmatic response, the 
      infiltration of leukocytes into bronchoalveolar lavage fluid, and an increase of 
      serum anti-ovalbumin IgE. These parameters were suppressed by the treatment with 
      TEI-9874 (3, 10, and 30 mg/kg p.o.). The ovalbumin-induced airway 
      hyperresponsiveness was prevented by TEI-9874 (30 mg/kg p.o.). Furthermore, the 
      suppression of the immediate-phase asthmatic response and the late-phase 
      asthmatic response by TEI-9874 was almost completely extinguished by the 
      exogenous administration of rat anti-ovalbumin antiserum. These results indicate 
      that the efficacy of TEI-9874 on the asthmatic response is mainly mediated by the 
      suppression of allergen-specific IgE production and TEI-9874 appears to be a good 
      candidate as therapy for IgE-mediated allergic asthma.
FAU - Nonaka, T
AU  - Nonaka T
AD  - Teijin Institute for Bio-Medical Research, 4-3-2, Asahigaoka, Hino, 191-8512, 
      Tokyo, Japan.
FAU - Mitsuhashi, H
AU  - Mitsuhashi H
FAU - Takahashi, K
AU  - Takahashi K
FAU - Sugiyama, H
AU  - Sugiyama H
FAU - Kishimoto, T
AU  - Kishimoto T
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (2-(4-(6-cyclohexyloxy-2-naphthyloxy)phenylacetamide)benzoic acid)
RN  - 0 (Allergens)
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Benzeneacetamides)
RN  - 0 (Benzoates)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Naphthalenes)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Allergens/*pharmacology
MH  - Animals
MH  - Anti-Asthmatic Agents/*pharmacology
MH  - Asthma/chemically induced/*prevention & control
MH  - *Benzeneacetamides
MH  - Benzoates/*pharmacology
MH  - Bronchial Hyperreactivity/chemically induced/prevention & control
MH  - Bronchoalveolar Lavage Fluid/cytology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Immunoglobulin E/analysis/*biosynthesis
MH  - Immunoglobulin G/analysis/biosynthesis
MH  - Indicators and Reagents
MH  - Methacholine Chloride/pharmacology
MH  - Naphthalenes/*pharmacology
MH  - Ovalbumin/immunology/pharmacology
MH  - Rats
MH  - Rats, Inbred BN
MH  - Respiratory Mechanics/drug effects
EDAT- 2000/08/26 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/26 11:00
PHST- 2000/08/26 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/26 11:00 [entrez]
AID - S0014299900005306 [pii]
AID - 10.1016/s0014-2999(00)00530-6 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2000 Aug 25;402(3):287-95. doi: 10.1016/s0014-2999(00)00530-6.